{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1364233270579835136.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1091/mbc.4.1.7"}}],"dc:title":[{"@value":"Connexin40, a component of gap junctions in vascular endothelium, is restricted in its ability to interact with other connexins."}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p> The cellular distribution of connexin40 (Cx40), a newly cloned gap junction structural protein, was examined by immunofluorescence microscopy using two different specific anti-peptide antibodies. Cx40 was detected in the endothelium of muscular as well as elastic arteries in a punctate pattern consistent with the known distribution of gap junctions. However, it was not detected in other cells of the vascular wall. By contrast, Cx43, another connexin present in the cardiovascular system, was not detected in endothelial cells of muscular arteries but was abundant in the myocardium and aortic smooth muscle. We have tested the ability of these connexins to interact functionally. Cx40 was functionally expressed in pairs of Xenopus oocytes and induced the formation of intercellular channels with unique voltage dependence. Unexpectedly, communication did not occur when oocytes expressing Cx40 were paired with those expressing Cx43, although each could interact with a different connexin, Cx37, to form gap junction channels in paired oocytes. These findings indicate that establishment of intercellular communication can be spatially regulated by the selective expression of different connexins and suggest a mechanism that may operate to control the extent of communication between cells. </jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1384233270579835137","@type":"Researcher","foaf:name":[{"@value":"R Bruzzone"}],"jpcoar:affiliationName":[{"@value":"Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, Massachusetts 02115."}]},{"@id":"https://cir.nii.ac.jp/crid/1384233270579835136","@type":"Researcher","foaf:name":[{"@value":"J A Haefliger"}],"jpcoar:affiliationName":[{"@value":"Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, Massachusetts 02115."}]},{"@id":"https://cir.nii.ac.jp/crid/1384233270579835139","@type":"Researcher","foaf:name":[{"@value":"R L Gimlich"}],"jpcoar:affiliationName":[{"@value":"Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, Massachusetts 02115."}]},{"@id":"https://cir.nii.ac.jp/crid/1384233270579835138","@type":"Researcher","foaf:name":[{"@value":"D L Paul"}],"jpcoar:affiliationName":[{"@value":"Department of Anatomy and Cellular Biology, Harvard Medical School, Boston, Massachusetts 02115."}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"10591524"},{"@type":"EISSN","@value":"19394586"}],"prism:publicationName":[{"@value":"Molecular Biology of the Cell"}],"dc:publisher":[{"@value":"American Society for Cell Biology (ASCB)"}],"prism:publicationDate":"1993-01","prism:volume":"4","prism:number":"1","prism:startingPage":"7","prism:endingPage":"20"},"reviewed":"false","createdAt":"2013-08-16","modifiedAt":"2019-07-14","relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360285707537703296","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Engineered Cx40 variants increased docking and function of heterotypic Cx40/Cx43 gap junction channels"}]},{"@id":"https://cir.nii.ac.jp/crid/1360846642075860608","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"The Physiological Characterization of Connexin41.8 and Connexin39.4, Which Are Involved in the Striped Pattern Formation of Zebrafish"}]},{"@id":"https://cir.nii.ac.jp/crid/1360848661337054464","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Induction of Genes Expressed in Endothelial Cells of the Corpus Callosum in the Chronic Cerebral Hypoperfusion Rat Model"}]}],"dataSourceIdentifier":[{"@type":"CROSSREF","@value":"10.1091/mbc.4.1.7"},{"@type":"CROSSREF","@value":"10.1159/000446876_references_DOI_8r2VUdyZLCmtvTtLejFakRukX5e"},{"@type":"CROSSREF","@value":"10.1074/jbc.m115.673129_references_DOI_8r2VUdyZLCmtvTtLejFakRukX5e"},{"@type":"CROSSREF","@value":"10.1016/j.yjmcc.2015.11.026_references_DOI_8r2VUdyZLCmtvTtLejFakRukX5e"}]}