{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1364233270956564608.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1083/jcb.147.6.1351"}},{"identifier":{"@type":"URI","@value":"https://rupress.org/jcb/article-pdf/147/6/1351/1856131/9906071.pdf"}},{"identifier":{"@type":"PMID","@value":"10601346"}},{"identifier":{"@type":"NAID","@value":"80011412233"}}],"dc:title":[{"@value":"Direct Binding of Three Tight Junction-Associated Maguks, Zo-1, Zo-2, and Zo-3, with the Cooh Termini of Claudins"}],"description":[{"type":"abstract","notation":[{"@value":"<jats:p>ZO-1, ZO-2, and ZO-3, which contain three PDZ domains (PDZ1 to -3), are concentrated at tight junctions (TJs) in epithelial cells. TJ strands are mainly composed of two distinct types of four-transmembrane proteins, occludin, and claudins, between which occludin was reported to directly bind to ZO-1/ZO-2/ZO-3. However, in occludin-deficient intestinal epithelial cells, ZO-1/ZO-2/ZO-3 were still recruited to TJs. We then examined the possible interactions between ZO-1/ZO-2/ZO-3 and claudins. ZO-1, ZO-2, and ZO-3 bound to the COOH-terminal YV sequence of claudin-1 to -8 through their PDZ1 domains in vitro. Then, claudin-1 or -2 was transfected into L fibroblasts, which express ZO-1 but not ZO-2 or ZO-3. Claudin-1 and -2 were concentrated at cell–cell borders in an elaborate network pattern, to which endogenous ZO-1 was recruited. When ZO-2 or ZO-3 were further transfected, both were recruited to the claudin-based networks together with endogenous ZO-1. Detailed analyses showed that ZO-2 and ZO-3 are recruited to the claudin-based networks through PDZ2 (ZO-2 or ZO-3)/PDZ2 (endogenous ZO-1) and PDZ1 (ZO-2 or ZO-3)/COOH-terminal YV (claudins) interactions. In good agreement, PDZ1 and PDZ2 domains of ZO-1/ZO-2/ZO-3 were also recruited to claudin-based TJs, when introduced into cultured epithelial cells. The possible molecular architecture of TJ plaque structures is discussed.</jats:p>"}]}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1384233270956564611","@type":"Researcher","foaf:name":[{"@value":"Masahiko Itoh"}],"jpcoar:affiliationName":[{"@value":"aDepartment of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1384233270956564612","@type":"Researcher","foaf:name":[{"@value":"Mikio Furuse"}],"jpcoar:affiliationName":[{"@value":"aDepartment of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1384233270956564609","@type":"Researcher","foaf:name":[{"@value":"Kazumasa Morita"}],"jpcoar:affiliationName":[{"@value":"aDepartment of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan"},{"@value":"bDepartment of Dermatology, Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1384233270956564608","@type":"Researcher","foaf:name":[{"@value":"Koji Kubota"}],"jpcoar:affiliationName":[{"@value":"aDepartment of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1384233270956564610","@type":"Researcher","foaf:name":[{"@value":"Mitinori Saitou"}],"jpcoar:affiliationName":[{"@value":"aDepartment of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan"}]},{"@id":"https://cir.nii.ac.jp/crid/1384233270956564613","@type":"Researcher","foaf:name":[{"@value":"Shoichiro Tsukita"}],"jpcoar:affiliationName":[{"@value":"aDepartment of Cell Biology, Faculty of Medicine, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00219525"},{"@type":"EISSN","@value":"15408140"}],"prism:publicationName":[{"@value":"The Journal of Cell Biology"}],"dc:publisher":[{"@value":"Rockefeller University Press"}],"prism:publicationDate":"1999-12-13","prism:volume":"147","prism:number":"6","prism:startingPage":"1351","prism:endingPage":"1363"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"https://rupress.org/jcb/article-pdf/147/6/1351/1856131/9906071.pdf"}],"createdAt":"2002-07-26","modifiedAt":"2023-07-29","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Recombinant%20Fusion%20Proteins","dc:title":"Recombinant Fusion Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Amino%20Acid%20Motifs","dc:title":"Amino Acid Motifs"},{"@id":"https://cir.nii.ac.jp/all?q=Transfection","dc:title":"Transfection"},{"@id":"https://cir.nii.ac.jp/all?q=Zonula%20Occludens-2%20Protein","dc:title":"Zonula Occludens-2 Protein"},{"@id":"https://cir.nii.ac.jp/all?q=Models,%20Biological","dc:title":"Models, Biological"},{"@id":"https://cir.nii.ac.jp/all?q=Tight%20Junctions","dc:title":"Tight Junctions"},{"@id":"https://cir.nii.ac.jp/all?q=Mice","dc:title":"Mice"},{"@id":"https://cir.nii.ac.jp/all?q=L%20Cells","dc:title":"L Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Occludin","dc:title":"Occludin"},{"@id":"https://cir.nii.ac.jp/all?q=Claudin-1","dc:title":"Claudin-1"},{"@id":"https://cir.nii.ac.jp/all?q=Animals","dc:title":"Animals"},{"@id":"https://cir.nii.ac.jp/all?q=Zonula%20Occludens%20Proteins","dc:title":"Zonula Occludens Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Amino%20Acid%20Sequence","dc:title":"Amino Acid Sequence"},{"@id":"https://cir.nii.ac.jp/all?q=Cells,%20Cultured","dc:title":"Cells, Cultured"},{"@id":"https://cir.nii.ac.jp/all?q=Mice,%20Knockout","dc:title":"Mice, Knockout"},{"@id":"https://cir.nii.ac.jp/all?q=Membrane%20Proteins","dc:title":"Membrane Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Epithelial%20Cells","dc:title":"Epithelial Cells"},{"@id":"https://cir.nii.ac.jp/all?q=Phosphoproteins","dc:title":"Phosphoproteins"},{"@id":"https://cir.nii.ac.jp/all?q=Intestines","dc:title":"Intestines"},{"@id":"https://cir.nii.ac.jp/all?q=Claudins","dc:title":"Claudins"},{"@id":"https://cir.nii.ac.jp/all?q=Zonula%20Occludens-1%20Protein","dc:title":"Zonula Occludens-1 Protein"},{"@id":"https://cir.nii.ac.jp/all?q=Carrier%20Proteins","dc:title":"Carrier Proteins"},{"@id":"https://cir.nii.ac.jp/all?q=Gene%20Deletion","dc:title":"Gene Deletion"},{"@id":"https://cir.nii.ac.jp/all?q=Protein%20Binding","dc:title":"Protein Binding"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360002219469856896","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Plakophilin-1, a Novel Wnt Signaling Regulator, Is Critical for Tooth Development and Ameloblast 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cells"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204632078592","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Percolation Analysis in Electrical Conductivity of Madin-Darby Canine Kidney and Caco-2 Cells by Permeation-Enhancing Agents"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679601752064","@type":"Article","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Telmisartan Increases the Permeability of Endothelial Cells through Zonula Occludens-1"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679673045120","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy","isCitedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Protamine-Induced Epithelial Barrier Disruption Involves Rearrangement of Cytoskeleton and Decreased Tight Junction-Associated Protein Expression in Cultured MDCK 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