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Synthesis of Some Pyridazinylacetic Acid Derivatives as a Novel Class of Monoamine Oxidase-A Inhibitors
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- Khattab Sherine Nabil
- Department of Chemistry, Faculty of Science, University of Alexandria
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- Bekhit Adnan Ahmed
- Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria
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- El-Faham Ayman
- Department of Chemistry, Faculty of Science, University of Alexandria
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- El Massry Abdel Moneim
- Department of Chemistry, Faculty of Science, University of Alexandria
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- Amer Adel
- Department of Chemistry, Faculty of Science, University of Alexandria
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Description
A series of new pyridazinylacetic acid derivatives were synthesized and have been investigated for their ability to inhibit the activity of the A and B isoforms of monoamine oxidase (MAO). All compounds were found to be more selective to the MAO-A isoform with compound 5d having the highest SI values. Computational study performed with a docking technique indicated the potential of these compounds in pyridazine-based MAO-A inhibitor drug development.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 56 (12), 1717-1721, 2008
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390001204168911872
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- NII Article ID
- 110007004704
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- NII Book ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 9715572
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL Search
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed