Development of Tubulin-Polymerization Inhibitors Based on the Thalidomide Skeleton
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- Aoyama Hiroshi
- Institute of Molecular & Cellular Biosciences, The University of Tokyo
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- Noguchi Tomomi
- Institute of Molecular & Cellular Biosciences, The University of Tokyo
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- Misawa Takashi
- Institute of Molecular & Cellular Biosciences, The University of Tokyo
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- Nakamura Takanori
- Institute of Molecular & Cellular Biosciences, The University of Tokyo
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- Miyachi Hiroyuki
- Institute of Molecular & Cellular Biosciences, The University of Tokyo
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- Hashimoto Yuichi
- Institute of Molecular & Cellular Biosciences, The University of Tokyo
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- Kobayashi Hisayoshi
- Institute of Molecular & Cellular Biosciences, The University of Tokyo
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Description
We synthesized a series of compounds based on the potent tubulin-polymerization inhibitor 5-hydroxy-2-(2,6-diisopropylphenyl)-1H-isoindole-1,3-dione [5HPP-33 (3)], which is structurally derived from thalidomide (1), and investigated their inhibitory effects on tubulin polymerization. Direct interaction between 5HPP-33 (3) and α,β-tubulin heterodimer protein was demonstrated by means of a surface plasmon resonance study.
Journal
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- Chemical and Pharmaceutical Bulletin
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Chemical and Pharmaceutical Bulletin 55 (6), 944-949, 2007
The Pharmaceutical Society of Japan
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Details 詳細情報について
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- CRID
- 1390001204170444160
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- NII Article ID
- 110006278705
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- NII Book ID
- AA00602100
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- COI
- 1:STN:280:DC%2BD2szivVCnsA%3D%3D
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- ISSN
- 13475223
- 00092363
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- NDL BIB ID
- 8741357
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- PubMed
- 17541201
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL Search
- Crossref
- CiNii Articles
- KAKEN
- OpenAIRE
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- Abstract License Flag
- Disallowed
