A New Diarylheptanoid Glycoside from the Stem Bark of Alnus hirsuta and Protective Effects of Diarylheptanoid Derivatives in Human HepG2 Cells
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- Park Daae
- Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University Doping Control Center, Research Coordination Division, Korea Institute of Science and Technology
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- Kim Hyoung Ja
- Bioanalysis and Biotransformation Research Center, Life Sciences Research Division, Korea Institute of Science and Technology
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- Jung Seo Yun
- Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University
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- Yook Chang-Soo
- Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University
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- Jin Changbae
- Doping Control Center, Research Coordination Division, Korea Institute of Science and Technology
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- Lee Yong Sup
- Department of Pharmaceutical Science, College of Pharmacy, Kyung Hee University
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説明
To search for secondary metabolites of Alnus hirsuta (Betulaceae), various chromatographic separations of the ethyl acetate soluble fraction of the stem bark of A. hirsuta led to the isolation of a new diarylheptanoid glycoside, (3R)-1,7-bis-(4-dihydroxyphenyl)-3-heptanol 3-O-β-D-glucopyranosyl(1→3)-β-D-xylopyranoside (13) and twelve diarylheptanoid derivatives, namely, oregonin (1), rubranoside A (2), hirsutanonol 5-O-β-D-glucopyranoside (3), rubranoside B (4), rubranoside C (5), hirsutanonol (6), hirsutenone (7), (5S)-O-methylhirsutanonol (8), platyphylloside (9), platyphyllonol 5-O-β-D-xylopyranoside (10), aceroside VII (11) and platyphyllenone (12). Isolates were assessed for their hepatoprotective effects against tert-butylhydroperoxide (t-BHP)-induced toxicity in HepG2 cells. Of these isolates, compounds 1—8 showed significant hepatoprotective effects on t-BHP-induced damage to HepG2 cells, with 8 exhibiting the greatest protective effect (50.7±3.7% at a concentration of 10 μM).
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 58 (2), 238-241, 2010
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390001204171738112
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- NII論文ID
- 130000161600
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 10537356
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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