Allergenicity Evaluation of Chemicals in Household Products (IX) Contact Allergenicity of Diethylene Glycol Monobutyl Ether (DEGBE), 2-Mercaptopyridine-N-Oxide Sodium (MPOS), and Zinc Dibenzyldithiocarbamate (ZBEC) in Guinea Pigs and Mice

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  • YAMANO Tetsuo
    Osaka City Institute of Public Health and Environmental Sciences
  • SHIMIZU Mitsuru
    Osaka City Institute of Public Health and Environmental Sciences

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  • 家庭用品に使用される化学物質の皮膚感作性（ＩＸ）　　ｄｉｅｔｈｙｌｅｎｅ　ｇｌｙｃｏｌ　ｍｏｎｏｂｕｔｙｌ　ｅｔｈｅｒ　（ＤＥＧＢＥ），２‐ｍｅｒｃａｐｔｏｐｙｒｉｄｉｎｅ‐Ｎ‐ｏｘｉｄｅ　ｓｏｄｉｕｍ　（ＭＰＯＳ），ｚｉｎｃ　ｄｉｂｅｎｚｙｌｄｉｔｈｉｏｃａｒｂａｍａｔｅ　（ＺＢＥＣ）　のモルモットおよびマウスにおける皮膚感作性
  • 家庭用品に使用される化学物質の皮膚感作性(9)diethylene glycol monobutyl ether(DEGBE)、2-mercaptopyridine-N-oxide sodium(MPOS)、zinc dibenzyldithiocarbamate(ZBEC)のモルモットおよびマウスにおける皮膚感作性
  • カテイ ヨウヒン ニ シヨウサレル カガク ブッシツ ノ ヒフ カンサセイ 9 diethylene glycol monobutyl ether DEGBE 2 mercaptopyridine N oxide sodium MPOS zinc dibenzyldithiocarbamate ZBEC ノ モルモット オヨビ マウス ニ オケル ヒフ カンサセイ
  • Contact Allergenicity of Diethylene Glycol Monobutyl Ether (DEGBE), 2-Mercaptopyridine-N-Oxide Sodium (MPOS), and Zinc Dibenzyldithiocarbamate (ZBEC) in Guinea Pigs and Mice
  • diethylene glycol monobutyl ether (DEGBE)、2-mercaptopyridine-N-oxide sodium (MPOS)、zinc dibenzyldithiocarbamate (ZBEC) のモルモットおよびマウスにおける皮膚感作性

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Three chemicals used in household products—diethylene glycol monobutyl ether (DEGBE), 2-mercaptopyridine-N-oxide sodium (MPOS), zinc dibenzyldithiocarbamate (ZBEC)—were evaluated for their skin sensitization potency in a modified guinea pig maximization test (GPMT) and non-radioactive murine local lymph-node assay (LLNA). In the GPMT, DEGBE failed to elicit a positive skin reaction even at maximum concentrations for the induction and elicitation procedures, whereas MPOS and ZBEC gave positive reactions. MPOS-induced animals cross-reacted to its analogous biocide, zinc pyrithione. In the LLNA, however, all three agents gave negative results. The results suggest that MPOS and ZBEC possess the intrinsic ability to cause skin sensitization, but the potency is not so high as to induce skin sensitization in mice through dermal exposure alone.

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