{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390001204244122368.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1620/tjem.237.339"}},{"identifier":{"@type":"PMID","@value":"26639092"}},{"identifier":{"@type":"URI","@value":"https://www.jstage.jst.go.jp/article/tjem/237/4/237_339/_pdf"}},{"identifier":{"@type":"NAID","@value":"130005112237"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2016359781"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Eldecalcitol, in Combination with Bisphosphonate, Is Effective for Treatment of Japanese Osteoporotic Patients"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Alfacalcidol (ALF) and eldecalcitol (ELD) are vitamin D analogues that can be combined with anti-resorption drugs, such as bisphosphonate (BP) for the treatment of osteoporosis (OP).  There has been no report comparing the effects of those vitamin D analogs in combination with BPs.  Twenty female patients with OP were enrolled, and all of them were treated with ALF and BPs.  After switching from ALF to ELD, we examined the effectiveness of ALF and ELD.  The averaged age was 69.4 years and the period of BP usage was between 1 to 13.4 years (mean period was 3.7 years).  Serum corrected calcium, serum inorganic phosphorus, serum bone specific alkaline phosphatase (BAP), and serum tartrate-resistant acid phosphatase (TRACP)-5b were measured prior to ELD and at 6 months afterwards.  Bone mineral density (BMD) of the lumbar spine (L-BMD), femoral neck, and total hip BMD were assessed one year before, prior to, and one year after ELD therapy commencement.  Six months after switching from ALF to ELD, BAP and TRACP-5b values significantly decreased.  After one year of ALF therapy, L-BMD, total hip BMD and femoral neck H-BMD values slightly increased.  In contrast, a year following the change from ALF to ELD, L-BMD significantly increased and femoral neck BMD slightly increased, but total hip BMD did not.  These results suggest that the treatment with ELD after ALF significantly suppressed bone turnover and increased L-BMD.  Thus, the combined therapy with ELD is more effective for OP treatment than that with ALF."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410001204244122368","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000311504515"}],"foaf:name":[{"@language":"en","@value":"Mukaiyama Keijiro"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Orthopedic Surgery, Shinshu University School of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658540200579","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10242679"},{"@type":"NRID","@value":"1000010242679"},{"@type":"NRID","@value":"9000003152477"},{"@type":"NRID","@value":"9000283743621"},{"@type":"NRID","@value":"9000255685803"},{"@type":"NRID","@value":"9000255980311"},{"@type":"NRID","@value":"9000258589554"},{"@type":"NRID","@value":"9000363172336"},{"@type":"NRID","@value":"9000020713995"},{"@type":"NRID","@value":"9000286632052"},{"@type":"NRID","@value":"9000255970252"},{"@type":"NRID","@value":"9000322101047"},{"@type":"NRID","@value":"9000255685521"},{"@type":"NRID","@value":"9000255974940"},{"@type":"NRID","@value":"9000309575478"},{"@type":"NRID","@value":"9000255690778"},{"@type":"NRID","@value":"9000402819644"},{"@type":"NRID","@value":"9000283691097"},{"@type":"NRID","@value":"9000018182184"},{"@type":"NRID","@value":"9000022157035"},{"@type":"NRID","@value":"9000380983201"},{"@type":"NRID","@value":"9000391806890"},{"@type":"NRID","@value":"9000350630672"},{"@type":"NRID","@value":"9000311504516"},{"@type":"NRID","@value":"9000258588915"},{"@type":"NRID","@value":"9000361296666"},{"@type":"NRID","@value":"9000020706730"},{"@type":"NRID","@value":"9000021627120"},{"@type":"NRID","@value":"9000255682470"},{"@type":"NRID","@value":"9000312254548"},{"@type":"NRID","@value":"9000402799861"},{"@type":"NRID","@value":"9000016810868"},{"@type":"NRID","@value":"9000242262215"}],"foaf:name":[{"@language":"en","@value":"Uchiyama Shigeharu"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Orthopedic Surgery, Shinshu University School of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204244122374","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000311504517"}],"foaf:name":[{"@language":"en","@value":"Nakamura Yukio"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Orthopedic Surgery, Shinshu University School of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204244122370","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000311504518"}],"foaf:name":[{"@language":"en","@value":"Ikegami Shota"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Orthopedic Surgery, Shinshu University School of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1420845751142589568","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70243582"},{"@type":"NRID","@value":"1000070243582"},{"@type":"NDL_AUTHOR_ID","@value":"001117867"},{"@type":"NRID","@value":"9000254174313"},{"@type":"NRID","@value":"9000256583606"},{"@type":"NRID","@value":"9000399749272"},{"@type":"NRID","@value":"9000254366196"},{"@type":"NRID","@value":"9000254619683"},{"@type":"NRID","@value":"9000254174088"},{"@type":"NRID","@value":"9000258692275"},{"@type":"NRID","@value":"9000267776510"},{"@type":"NRID","@value":"9000254174051"},{"@type":"NRID","@value":"9000400183975"},{"@type":"NRID","@value":"9000311504519"},{"@type":"NRID","@value":"9000258383222"},{"@type":"NRID","@value":"9000403306490"},{"@type":"NRID","@value":"9000254174394"},{"@type":"NRID","@value":"9000391505285"},{"@type":"NRID","@value":"9000402937204"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0016688"}],"foaf:name":[{"@language":"en","@value":"Taguchi Akira"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Oral and Maxillofacial Radiology, Matsumoto Dental University"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204244122371","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000311504521"}],"foaf:name":[{"@language":"en","@value":"Kato Hiroyuki"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Orthopedic Surgery, Shinshu University School of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204244122372","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000311504520"}],"foaf:name":[{"@language":"en","@value":"Kamimura Mikio"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Center for Osteoporosis and Spinal Disorders, Kamimura Orthopaedic Clinic"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00408727"},{"@type":"EISSN","@value":"13493329"}],"prism:publicationName":[{"@language":"en","@value":"The Tohoku Journal of Experimental Medicine"},{"@language":"en","@value":"Tohoku J. Exp. Med."}],"dc:publisher":[{"@language":"en","@value":"Tohoku University Medical Press"},{"@language":"ja","@value":"東北ジャーナル刊行会"}],"prism:publicationDate":"2015","prism:volume":"237","prism:number":"4","prism:startingPage":"339","prism:endingPage":"343"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"https://www.jstage.jst.go.jp/article/tjem/237/4/237_339/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2016359781"}],"availableAt":"2015","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=alfacalcidol","dc:title":"alfacalcidol"},{"@id":"https://cir.nii.ac.jp/all?q=bisphosphonate","dc:title":"bisphosphonate"},{"@id":"https://cir.nii.ac.jp/all?q=combination%20therapy","dc:title":"combination therapy"},{"@id":"https://cir.nii.ac.jp/all?q=eldecalcitol","dc:title":"eldecalcitol"},{"@id":"https://cir.nii.ac.jp/all?q=osteoporosis","dc:title":"osteoporosis"}],"project":[{"@id":"https://cir.nii.ac.jp/crid/1040282256830650496","@type":"Project","projectIdentifier":[{"@type":"KAKEN","@value":"15K11092"},{"@type":"JGN","@value":"JP15K11092"},{"@type":"URI","@value":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K11092/"}],"notation":[{"@language":"ja","@value":"口腔顎顔面のエックス線画像指標を統合した新規骨粗鬆症スクリーニングシステムの構築"},{"@language":"en","@value":"Construction of the new osteoporosis screening system which unified indices detected on oral and maxillofacial image"}]}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1050850247204971008","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effect of eldecalcitol, an active vitamin D analog, on hip structure and biomechanical properties: 3D assessment by clinical 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(ED-71)"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845002932736","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Vitamin D<sub>3</sub> analogs for the treatment of osteoporosis"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318231276160","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"ED-71, a new active vitamin D3, increases bone mineral density regardless of serum 25(OH)D levels in osteoporotic subjects"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320495544832","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"N-of-1 Trials in the Medical Literature"}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204242669952","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Alfacalcidol Increases the Therapeutic Efficacy of Ibandronate on Bone Mineral Density in Japanese Women with Primary 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