Soy protein diet prevents hypermethioninemia caused by portacaval shunt in rats

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  • Shimooka Rie
    Department of Nutrition and Health Promotion, Faculty for Human Life Science, Hiroshima Jogakuin University
  • Yasuhiro Kido
    Department of Food Sciences and Nutritional Health, Faculty of Human Environment, Kyoto Prefectural University
  • Chiba Naoko
    Department of Nutritional Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School
  • Tanaka Junko
    Department of Nutritional Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School
  • Rokutan Kazuhito
    Department of Stress Science, Institute of Proteomics Medical Science, The University of Tokushima Graduate School
  • Furochi Harumi
    Department of Nutritional Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School
  • Hirasaka Katsuya
    Department of Nutritional Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School
  • Nikawa Takeshi
    Department of Nutritional Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School
  • Kishi Kyoichi
    Department of Nutritional Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School

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In hepatic disorders, abnormal plasma amino acid profiles are observed. In this study, we examined whether soy protein isolate (SPI) improved plasma methionine concentration in the model animals. Portacaval shunt (PCS) increased alanine aminotransferase (ALT) activity and methionine concentration in blood of rats fed a 40% casein diet supplemented with 0.6% methionine (casein-M diet). A 40% SPI diet supplemented with 1.28% methionine (SPI-M diet), which contained the same amount of methionine as that in 40% casein-M diet, normalized plasma ALT activity and methionine level in PCS rats.These effects of a SPI diet may be due to its amino acid composition, since an amino acid mixture diet mimicking a 40% SPI-M diet was also effective to hypermethioninemia of PCS rats. To find key enzymes for the beneficial effect of soy protein, we examined effects of a 40% SPI-M or casein-M diet on the activities of three methionine-metabolizing enzymes in liver of PCS rats. A SPI-M diet stimulated only the activity of cystathionine γ-lyase, compared with a casein-M diet. A SPI diet has a preventive effect on hypermethioninemia, at least in part, by stimulating cystathionine γ-lyase activity in liver and may be used for nutritional management of liver disorders with hypermethioninemia. J. Med. Invest. 53: 255-263, August, 2006

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