アレルギー性鼻炎におけるヒスタミンH<sub>1</sub>受容体遺伝子発現亢進の分子機構とその制御

  • 北村 嘉章
    徳島大学大学院ヘルスバイオサイエンス研究部耳鼻咽喉科学分野
  • 水口 博之
    徳島大学大学院ヘルスバイオサイエンス研究部分子情報薬理学分野
  • 福井 裕行
    徳島大学大学院ヘルスバイオサイエンス研究部分子情報薬理学分野
  • 武田 憲昭
    徳島大学大学院ヘルスバイオサイエンス研究部耳鼻咽喉科学分野

書誌事項

タイトル別名
  • The Molecular Mechanism of Up-regulation of Histamine H<sub>1</sub> Receptor mRNA in the Nasal Mucosa of Patients with Allergic Rhinitis and the Effect of Antihistamine on Histamine H<sub>1</sub> Receptor Expression
  • アレルギー性鼻炎におけるヒスタミンH₁受容体遺伝子発現亢進の分子機構とその制御
  • アレルギーセイ ビエン ニ オケル ヒスタミン H ₁ ジュヨウタイ イデンシ ハツゲン コウシン ノ ブンシ キコウ ト ソノ セイギョ
  • The Molecular Mechanism of Up-regulation of Histamine H1 Receptor mRNA in the Nasal Mucosa of Patients with Allergic Rhinitis and the Effect of Antihistamine on Histamine H1 Receptor Expression

この論文をさがす

抄録

We are focusing on the histamine H1 receptor (H1R) as an allergic disease-sensitive gene. H1R is a rate-limiting molecule of the H1R signal because the signal is increased with elevated receptor expression levels. We discovered that the direct stimulation of H1R induced the up-regulation of H1R gene expression through PKCδ activation. The mechanism of H1R gene expression was revealed to play a key role in the receptor expression level in studies using cultured HeLa cells and allergic rhinitis model rats. Antihistamines have three effects: the blocking effect on histamine signaling of H1 receptors; the suppressive effect on histamine-induced up-regulation of H1R mRNA that is the transcriptional activation of H1R; and the suppressive effect on H1R mRNA in the absence of histamine that is the basal transcription of H1R. The third effect may be another side of the inverse agonist action of antihistamine. We demonstrated that repeated pretreatment with antihistamines in the allergic rhinitis model rats resulted not only in the improvement of symptoms but also in the suppression of the up-regulation of H1R mRNA in the nasal mucosa. We next investigated the effect of preseasonal prophylactic treatment with antihistamines on nasal symptoms and the expression of H1R mRNA of the nasal mucosa in patients with cedar pollen pollinosis. During the peak pollen period, the expression of H1R mRNA in the nasal mucosa and the scores of sneezing and watery rhinorrhea in patients receiving preseasonal prophylactic treatment with antihistamines were significantly suppressed in comparison with those in the patients without treatment. These results suggest that H1R is an allergic disease-sensitive gene and H1R plays an important role in allergic rhinitis through the regulation of histamine signaling.

収録刊行物

被引用文献 (1)*注記

もっと見る

参考文献 (3)*注記

もっと見る

関連プロジェクト

もっと見る

詳細情報

問題の指摘

ページトップへ