Protective Effect of MKC-231, a Novel High Affinity Choline Uptake Enhancer, on Glutamate Cytotoxicity in Cultured Cortical Neurons.
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- Akaike Akinori
- Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
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- Maeda Takehiko
- Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University
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- Kaneko Satoshi
- Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Kyoto University Present address: Yokohama Research Center, Mitsubishi Chemical Corporation
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- Tamura Yutaka
- Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University
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- タイトル別名
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- Protective Effect of MKC-231 a Novel Hi
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This study was performed to examine the neuroprotective action of 2-(2-oxopyrrolidin-1-yl)-N-(2, 3-dimethyl-5, 6, 7, 8-tetrahydrofuro[2, 3-b]quinolin-4-yl)acetoamide (MKC-231), which enhances choline uptake and acetylcholine release in the central nervous system. Glutamate neurotoxicity was assessed with cortical cultures obtained from fetal rats. Exposure of cultures to MKC-231 for 12 – 24 hr ameliorated glutamate cytotoxicity. MKC-231 reduced cytotoxicity induced by ionomycin, a calcium ionophore, but did not affect the cytotoxicity induced by S-nitrosocysteine, a nitric oxide (NO) donor. These findings suggest that MKC-231 protects against glutamate neurotoxicity by suppressing the NO formation triggered by Ca2+-influx.
収録刊行物
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- Jpn.J.Pharmacol.
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Jpn.J.Pharmacol. 76 (2), 219-222, 1998
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390001204286046336
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- NII論文ID
- 10008191680
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- NII書誌ID
- AA00691188
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- COI
- 1:CAS:528:DyaK1cXht12nt7w%3D
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- ISSN
- 13473506
- 00215198
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- NDL書誌ID
- 4416249
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- PubMed
- 9541286
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- Web Site
- https://ndlsearch.ndl.go.jp/books/R000000004-I4416249
- https://api.elsevier.com/content/article/PII:S0021519819312326?httpAccept=text/xml
- https://api.elsevier.com/content/article/PII:S0021519819312326?httpAccept=text/plain
- https://www.jstage.jst.go.jp/article/jjp/76/2/76_2_219/_pdf
- https://search.jamas.or.jp/link/ui/1998195560
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- PubMed
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