SERUM β-GLUCURONIDASE AND β-ACETYLGLUCOSAMINASE ACTIVITIES IN EXPERIMENTAL DIABETIC RABBITS

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  • SHIOYA AKITOSHI
    Department of Pharmacology, Division of Biology, Research Laboratories, Chugai Pharmaceutical Co., Ltd.
  • OHISHI IWAO
    Department of Pharmacology, Division of Biology, Research Laboratories, Chugai Pharmaceutical Co., Ltd.
  • KAKIMOTO MORIO
    Department of Pharmacology, Division of Biology, Research Laboratories, Chugai Pharmaceutical Co., Ltd.

Bibliographic Information

Other Title
  • Serum ベータ-glucuronidase and ベータ-acetylglucosaminase activities in experimental diabetic rabbits
Published
1968
Resource Type
journal article
DOI
  • 10.1254/jjp.18.104
Publisher
The Japanese Pharmacological Society

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Description

In a previous paper (1), the authors demonstrated that changes in serum β-glucuronidase activity paralleled blood sugar levels after the administration of glucose, epinephrine and insulin, while an inverse relationship was found with hydrocortisone treatment. Furthermore, we observed that the changes in serum β-acetylglucosaminase activity in such cases were somewhat different from that of β-glucuronidase. On the other hand, several investigators (2-7) have shown an increase in serum β-glucuronidase activity of diabetic patients. Among them, however, only Woolen and Turner (6) has observed a significant correlation between plasma β-glucuronidase activity and blood sugar levels. In the present study we have extended our survey of the relationship between serum β-glucuronidase activity and the blood sugar level in experimental diabetic rabbits, prepared by a single injection of alloxan or consecutive administrarion of hydrocortisone.

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