SERUM β-GLUCURONIDASE ACTIVITY FOLLOWING THE ADMINISTRATION OF VARIOUS SUGARS AND ANTIDIABETICS IN RABBITS

OHISHI IWAO, SHIOYA AKITOSHI

doi:10.1254/jjp.20.44

A close positive correlation has been found in this laboratory between serum β-glucuronidase activity and blood glucose level immediately following administration of glucose, epinephrine and insulin to normal fasted rabbits (1). Similar correlation has also been shown in hyperglycemia of a long term produced by alloxan administration to rabbits (2). On the other hand, it has been known that serum β-glucuronidase activity is higher in diabetic patients than in normal subjects (3-9). In view of the possible bearing of the serum β-glucuronidase-blood glucose level correlation on diabetes mellitus in man, it was felt essentially important to investigate this relationship in more detail.<BR> There are several questions to be answered in this study: 1) dose the serum β-glucuronidase activity increase occur following administration of sugars other than glucose; 2) specifically, is it not merely due to physicochemical changes of blood such as the increase in the osmolarity; 3) if this phenomenon is specific for certain sugars, is such specificity related to possible disturbances in glucose metabolism ; and, 4) what effects do different types of antidiabetics have on serum β-glucuronidase activity.<BR> The study reported here thus describes the relationships between the serum β-glucuronidase activity and blood glucose level and between the activity and the levels of administered sugars, following administration of various sugars and antidiabetics to rabbits.

SERUM β-GLUCURONIDASE ACTIVITY FOLLOWING THE ADMINISTRATION OF VARIOUS SUGARS AND ANTIDIABETICS IN RABBITS

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