{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390001204289616640.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1254/jjp.24.589"}},{"identifier":{"@type":"COI","@value":"1:CAS:528:DyaE2MXltFGhsg%3D%3D"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"7673382"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/7673382"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I7673382"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0021519819612588?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0021519819612588?httpAccept=text/plain"}},{"identifier":{"@type":"PMID","@value":"4455968"}},{"identifier":{"@type":"NAID","@value":"130000838441"}}],"dc:title":[{"@language":"en","@value":"ANTIARRHYTHMIC ACTIVITY OF 1-(7-INDENYLOXY)-3-ISOPROPYLAMINOPROPANE-2-OL HYDROCHLORIDE (YB-2) AND ITS OPTICAL ISOMERS"},{"@value":"Antiarrhythmic activity of l-(7-indenyloxy)-3-isopropylaminopropane-2-ol hydrochloride(YB-2)and its optical isomers"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"The antiarrhythmic activities of YB-2 and its optical isomers were investigated in experimentally induced arrhythmias in anesthetized guinea pigs and dogs, and compared with those of propranolol. The local anesthetic and negative inotropic properties of these agents were also examined because of their possible contribution to the antiarrhythmic profile. In anesthetized guinea pigs, these agents showed a significant protecting effect against ouabain-induced arrhythmias; tile order of the potency was as follows, 1-YB-2=dl-YB-2>propranolol>d-YB-2. The similar tendency was also observed in anesthetized dogs. YB-2 and its 1-isomer, 0.1-0.4 mg/kg i.v., were equipotent with propranolol with respect to their protecting effects against methylchloroform-epinephrine-induced ventricular fibrillation in dogs, while the d-isomer, 4 mg/kg i.v., failed to inhibit the arrhythmias. YB-2 and its optical isomers and propranolol were found to have significant local anesthetic activities in guinea pig cornea and dorsal skin and negative inotropic activities in isolated guinea pig atria. There was no significant difference among these agents in each activity. The results suggest that YB-2 and its optical isomers appear to have a similar potency ratio for antiarrhythmic activity as is the case with propranolol and its optical isomers, and that YB-2 may prove to be a useful antiarrhythmic agent in clinical situations."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410001204289616642","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000020518679"}],"foaf:name":[{"@language":"en","@value":"KATO Hitoshi"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204289616641","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000020518685"}],"foaf:name":[{"@language":"en","@value":"NOGUCHI Yuji"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204289616640","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000020518693"}],"foaf:name":[{"@language":"en","@value":"TAKAGI Keijiro"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00215198"},{"@type":"EISSN","@value":"13473506"},{"@type":"NDL_BIB_ID","@value":"000000120551"},{"@type":"ISSN","@value":"00215198"},{"@type":"LISSN","@value":"00215198"},{"@type":"NCID","@value":"AA00691188"}],"prism:publicationName":[{"@language":"en","@value":"The Japanese Journal of Pharmacology"},{"@language":"en","@value":"Jpn.J.Pharmacol"},{"@language":"ja","@value":"Jpn.J.Pharmacol."}],"dc:publisher":[{"@language":"en","@value":"The Japanese Pharmacological Society"},{"@language":"ja","@value":"公益社団法人 日本薬理学会"}],"prism:publicationDate":"1974","prism:volume":"24","prism:number":"4","prism:startingPage":"589","prism:endingPage":"599"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://id.ndl.go.jp/bib/7673382"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I7673382"},{"@id":"https://api.elsevier.com/content/article/PII:S0021519819612588?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0021519819612588?httpAccept=text/plain"}],"availableAt":"1974","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Pharmacology","dc:title":"Pharmacology"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011143786072704","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"SELECTIVE BLOCKADE OF ADRENOCEPTIVE BETA RECEPTORS IN THE HEART"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620962190336","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"ANTIARRHYTHMIC EFFECTS OF <i>BETA</i> ADRENERGIC BLOCKING AGENTS*"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574094704609792","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Optical Isomers of Propranolol"}]},{"@id":"https://cir.nii.ac.jp/crid/1360574095560535680","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The relevance of β‐receptor blockade to ouabain‐induced cardiac arrhythmias"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046382854016","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effect of Quinidine and Pronethalol on Acetylstrophanthidin-Induced Ventricular Arrhythmia in Cats Treated with Reserpine"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519015306880","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"THE EFFECTS OF PRONETHALOL, DICHLOROISOPRENALINE AND DISOPYRAMIDE ON THE TOXICITY TO THE HEART OF OUABAIN AND ANAESTHETICS"}]},{"@id":"https://cir.nii.ac.jp/crid/1361418519414838272","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Inotropie and Chronotropic Effects of a Series of  -Adrenergic Blocking Drugs: Some Structure-Activity Relationships."}]},{"@id":"https://cir.nii.ac.jp/crid/1361418521061486592","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Evidence for Adrenergic Mediation of Ouabain induced Arrhythmias in the Guinea Pig"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994978170496","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Antiarrhythmic Action of 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Dogs"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388844864345216","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cardiac Sympathetic Nerve Activity: Changes Induced by Ouabain and Propranolol"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670318873876224","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Nature of the calcium dependent potassium leak induced by (+)‐propranolol, and its possible relevance to the drug's antiarrhythmic effect"}]},{"@id":"https://cir.nii.ac.jp/crid/1363670320771995776","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Some Pharmacological Properties of a New β‐Adrenergic Blocking Agent, 1‐(isopropylamino)‐3‐(o‐phenoxyphenoxy)‐2‐propanol, HCI (Ph QA 33)."}]},{"@id":"https://cir.nii.ac.jp/crid/1390001204290715264","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"CARDIOVASCULAR BETA-ADRENERGIC RECEPTOR BLOCKING ACTIVITIES OF 1-(7-INDENYLOXY)-3-ISOPROPYL-AMINOPROPANE-2-OL HYDROCHLORIDE (YB-2) AND ITS OPTICAL ISOMERS"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679265385728","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["references"],"jpcoar:relatedTitle":[{"@language":"en","@value":"PHARMACOLOGICAL STUDIES OF PANAX GINSENG LEAVES"},{"@value":"Pharmacological studies of panax sinseng leaves"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0029357617"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I7673382"},{"@type":"CROSSREF","@value":"10.1254/jjp.24.589"},{"@type":"CIA","@value":"130000838441"},{"@type":"OPENAIRE","@value":"doi_dedup___::a31a99841c70d3123cc3e745560446e6"}]}