EFFECTS OF CORTICOSTEROIDS ON THE RELEASE OF MEDIATORS IN ANAPHYLAXIS OF SENSITIZED GUINEA PIG TISSUES

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  • KURIHARA Norio
    Department of Pharmacology, School of Medicine, Gunma University

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  • Effects of corticosteroids on the relea

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Anaphylaxis was induced in vitro in the small intestine, lung, aorta and heart of activity sensitized guinea pigs by adding the antigen after immersion in Tyrode solution, and released histamine and 5-HT were spectrophotofluorometrically determined to investigate the effect of corticosteroids on the releases. Dexamethasone administration markedly reduced the release of histamine and 5-HT in anaphylaxis, but DOCA exerted no effect on the release of these mediators from the tissues. On the other hand, aldosterone significantly decreased the release of histamine from the tissues in anaphylaxis, but did not produce any reduction in the release of 5-HT. The authors previously spectrophotofluorometrically determined the amount of mediators released from tissues of sensitized guinea pigs by addition of an antigen, and reported that while histamine was released on application of the antigen, 5-hydroxytryptamine (5-HT) was spontaneously released without antigen application (1). The purpose of the present experiment was to investigate the effect of corticosteroids on the release of the mediators from tissues of sensitized guinea pigs in anaphylaxis.

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