{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390001204289830784.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1254/jjp.13.186"}},{"identifier":{"@type":"PMID","@value":"14062711"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"9245619"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/9245619"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I9245619"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0021519819644689?httpAccept=text/xml"}},{"identifier":{"@type":"URI","@value":"https://api.elsevier.com/content/article/PII:S0021519819644689?httpAccept=text/plain"}},{"identifier":{"@type":"NAID","@value":"130000836111"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/1964004420"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"STRUCTURE AND ACTIVITY RELATIONSHIP OF MONOAMINE OXIDASE INHIBITORS, PHENYLACETYLHYDRAZIDE DERIVATIVES"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Since the introduction of iproniazid, originally synthesized as antitubercular drug, monoamine oxidase (MAO) inhibitors have been applied to the treatment of mental depression and angina pectoris. Most of the MAO inhibitors are chemically hydrazine and hydrazide derivatives. It is suggested by many investigators that pharmacological effects of the inhibitors derive from accumulation of serotonin and catecholamines in the central nervous system and other organs. The socalled side effects of the inhibitors such as liver damage are supposed to be due to unknown direct effects. Efforts to find out less toxic inhibitors have been done, thereupon.<BR> The present paper describes the structure-activity relationship of new MAO inhibitors, phenylacetylhydrazide derivatives by use of iproniazid and phenylisopropylhydrazine (JB-516) as control. The chemical structures of the derivatives are shown in Fig. 1."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410009221963567234","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000022042051"}],"foaf:name":[{"@language":"en","@value":"NAKAMURA KEIJI"},{"@language":"ja","@value":"中村 圭二"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Pharmacological Division, Dainippon Pharmaceutical Co. Research Laboratories"},{"@language":"ja","@value":"Pharmacological Division, Dainippon Pharmaceutical Co. Research Laboratories"}]},{"@id":"https://cir.nii.ac.jp/crid/1410009221963567233","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000022042052"}],"foaf:name":[{"@language":"en","@value":"MASUDA YOSHINOBU"},{"@language":"ja","@value":"増田 義信"}],"jpcoar:affiliationName":[{"@language":"ja","@value":"Pharmacological Division, Dainippon Pharmaceutical Co. Research Laboratories"},{"@language":"en","@value":"Pharmacological Division, Dainippon Pharmaceutical Co. Research Laboratories"}]},{"@id":"https://cir.nii.ac.jp/crid/1410009221963567104","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000022042053"}],"foaf:name":[{"@language":"en","@value":"TATSUMI HIROSHI"},{"@language":"ja","@value":"辰己 煕"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Pharmacological Division, Dainippon Pharmaceutical Co. Research Laboratories"},{"@language":"ja","@value":"Pharmacological Division, Dainippon Pharmaceutical Co. Research Laboratories"}]},{"@id":"https://cir.nii.ac.jp/crid/1410009221963567232","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000022042054"}],"foaf:name":[{"@language":"en","@value":"FUJIMOTO KATSURO"},{"@language":"ja","@value":"藤本 克郎"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Pharmacological Division, Dainippon Pharmaceutical Co. Research Laboratories"},{"@language":"ja","@value":"Pharmacological Division, Dainippon Pharmaceutical Co. Research Laboratories"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"00215198"},{"@type":"EISSN","@value":"13473506"},{"@type":"NDL_BIB_ID","@value":"000000120551"},{"@type":"ISSN","@value":"00215198"},{"@type":"LISSN","@value":"00215198"},{"@type":"NCID","@value":"AA00691188"}],"prism:publicationName":[{"@language":"en","@value":"The Japanese Journal of Pharmacology"},{"@language":"en","@value":"Jpn.J.Pharmacol"},{"@language":"ja","@value":"Jpn.J.Pharmacol."}],"dc:publisher":[{"@language":"en","@value":"The Japanese Pharmacological Society"},{"@language":"ja","@value":"公益社団法人 日本薬理学会"}],"prism:publicationDate":"1963","prism:volume":"13","prism:number":"2","prism:startingPage":"186","prism:endingPage":"194"},"reviewed":"false","url":[{"@id":"http://id.ndl.go.jp/bib/9245619"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I9245619"},{"@id":"https://api.elsevier.com/content/article/PII:S0021519819644689?httpAccept=text/xml"},{"@id":"https://api.elsevier.com/content/article/PII:S0021519819644689?httpAccept=text/plain"},{"@id":"https://search.jamas.or.jp/link/ui/1964004420"}],"availableAt":"1963","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Pharmacology","dc:title":"Pharmacology"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011144006131200","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"AMINE OXIDASES"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011145083597440","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"The oxidation of adrenaline and other amines"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146239318784","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Effect of antitubercular drugs on the metabolism of histamine and sympathicomimetic amines"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995253723008","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"ANTICONVULSANT PROPERTIES OF MONOAMINE OXIDASE INHIBITORS"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262944004519424","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"PROPERTIES OF MAXIMAL SEIZURES, AND THEIR ALTERATION BY ANTICONVULSANT DRUGS AND OTHER AGENTS"}]},{"@id":"https://cir.nii.ac.jp/crid/1363107369570190592","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"In vivo Inhibition of Liver and Brain Monoamine Oxidase by 1-Isonicotinyl-2-Isopropyl Hydrazine."}]},{"@id":"https://cir.nii.ac.jp/crid/1364233270663019520","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"INTERACTION OF MONOAMINE OXIDASE INHIBITORS WITH PHYSIOLOGICAL AND BIOCHEMICAL MECHANISMS IN BRAIN"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0029144591"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I9245619"},{"@type":"CROSSREF","@value":"10.1254/jjp.13.186"},{"@type":"PUBMED","@value":"14062711"},{"@type":"CIA","@value":"130000836111"}]}