Effects of 1,25-dihydroxyvitamin D3 on cultured human hair follicle cells.

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Other Title
  • １，２５‐Ｄｉｈｙｄｒｏｘｙｖｉｔａｍｉｎ　Ｄ３のＨａｉｒ　Ｆｏｌｌｉｃｌｅ　Ｃｅｌｌｓに与える影響
Published
1989
DOI
  • 10.2336/nishinihonhifu.51.59
Publisher
Western Division of Japanese Dermatological Association

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The effects of 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) on the growth and differentiation of cultured human hair follicle cells (HFC) were studied. 1,25(OH)2D3 markedly affected the growth of HFC. It caused a dose-dependent decrease in both plating efficiency and colony growth, and inhibited DNA synthesis of HFC. 1,25(OH)2D3 also caused an increase in cell size, stimulating cornified envelope formation, and inducing morphological changes in HFC which showed terminal differentiation in vitro. HFC was confirmed to consist of target cells. 1,25(OH)2D3 seems to be a potent inhibitor of proliferation as well as a potent stimulator of terminal differentiation of human HFC. Our findings may give helpful clues towards the mechanism of alopecia seen in patients with vitamin D-dependent rickets type II.

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