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cells."},{"@language":"ja","@value":"表皮細胞におけるプロテイン・キナーゼＣの役割"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"ja","@value":"腫瘍プロモーターである12-0-テトラデカノイルホルボール-13-アセテート(TPA)は表皮細胞の増殖や分化に著明な作用を及ぼす。このTPAはプロテイン·キナーゼC(PKC)を直接的に活性化する。よつてPKCが表皮細胞の増殖, 分化に重要な役割を担つている可能性が強い。本綜説ではPKCの表皮細胞の増殖, 分化における役割を, マウス表皮細胞を用いた実験結果と, 尋常性乾癬の病巣部表皮におけるPKCの検索成績に基づき, PKCのダウン·レギュレーション, PKCの多様性といつた点について述べた。さらにPKCの作用点, PKCと癌遺伝子, 増殖因子との関連性といつた将来への展望についても考察を加えた。"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410001204299622144","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000283305781"}],"foaf:name":[{"@language":"ja","@value":"立石 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Association"},{"@language":"ja","@value":"日本皮膚科学会西部支部"}],"prism:publicationDate":"1989","prism:volume":"51","prism:number":"5","prism:startingPage":"871","prism:endingPage":"876"},"reviewed":"false","url":[{"@id":"https://search.jamas.or.jp/link/ui/1991077653"}],"availableAt":"1989","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=Dermatology","dc:title":"Dermatology"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011144531463168","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Application of phorbol ester to mouse skin causes a rapid and sustained loss of protein kinase C"}]},{"@id":"https://cir.nii.ac.jp/crid/1360011146088550144","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cyclic Amp Accumulation in Psoriatic Skin: Differential Responses to Histamine, Amp, and Epinephrine by the Uninvolved and Involved 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