Overlapping Syndrome with Angio-Immunoblastic Lymphadenopathy (Frizzera)

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Other Title
  • Angio-Immunoblastic Lymphadenopathy(Frizzera)様のリンパ節所見を呈したOverlap症候群
  • Angio-Immunoblastic Lymphadenopathy(Frizzera)様のリンパ節所見を呈したOverlap症候群--とくにImmunoblastic Lymphadenopathy(Lukes),Angio-Immunoblastic Lymphadenopathy,Immunodysplasia Syndrome(畔柳)との異同について
  • Angio Immunoblastic Lymphadenopathy Fri
  • —With Special Reference to Relationship of Immunoblastic Lymphadenopathy (Lukes), Angio-Immunoblastic Lymphadenopathy and Immunodysplasia Syndrome (Kuroyanagi)—
  • —とくにImmunoblastic Lymphadenopathy(Lukes), Angio-Immunoblastic Lymphadenopathy, Immunodysplasia Syndrome(畔柳)との異同について—
Published
1978
DOI
  • 10.2336/nishinihonhifu.40.629
Publisher
Western Division of Japanese Dermatological Association

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Description

A 28-year-old woman with angio-immunoblastic lymphadenopathy and overlapping syndrome was reported. Her condition was started with fever and pruritic erythema following oral administration of antipyretics. One month later muscle tenderness, weakness of the lower extremities, arthralgia and acrosclerosis developed. Those symptoms were persistent for two years despite systemic administration of corticosteroid. In May 1976, she was admitted to our clinic for Raynaud’s phenomenon, acrosclerosis, pain in the left chest and fever. Physical examination on admission showed hepatosplenomegaly, systemic lymphadenopathy, retention of pleural fluid and oral aphthae. A lymphnode biopsy showed enlarged follicles, proliferation of capillary vessels, an increased number of immunoblasts and deposits of PAS positive granules around the immunoblasts. Those histological findings were consistent with those of angio-immunoblastic lymphadenopathy. Although clinical pictures of our case simulated progressive systemic sclerosis and laboratory data suggested dermatomyositis or systemic lupus erythematosus, we diagnosed our case as an overlapping syndrome (type II. Oofuji’s classification), because only some findings of our case corresponded to a few diagnostic criteria of each collagen disease. On the other hand, there is no paper reporting the details of histological pictures of lymphnode of patients with an overlapping syndrome. Furthermore, there is no report that the skin symptoms and laboratory data of angio-immunoblastic lymphadenopathy were suggestive of any collagen disease. Therefore, we considered that our case should be a combined case of angio-immunoblastic lymphadenopathy and overllapping syndrome.

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