小児唾液クロモグラニンA,アミラーゼのストレス指標としての有効性

  • 光畑 智恵子
    広島大学大学院医歯薬学総合研究科創生医科学専攻顎口腔頚部医科学講座小児歯科学研究室
  • 鈴木 淳司
    広島大学大学院医歯薬学総合研究科創生医科学専攻顎口腔頚部医科学講座小児歯科学研究室
  • 香西 克之
    広島大学大学院医歯薬学総合研究科創生医科学専攻顎口腔頚部医科学講座小児歯科学研究室

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  • The effectiveness of salivary chromogranin A and amylase as stress indicators in children

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It has been reported that chromogranin A (CgA) cg and amylase (Aml) in saliva could be useful indicators of stress in adults. This study sought to verify whether saliva chromogranin A and amylase may also be used as indices of stress in children. We measured the concentration of CgA and Aml in saliva collected from twenty-four children before and after dental treatment and also performed the Dental Sub-scale of the Children's Fear Schedule (CFSS-DS) examination on all children. The concentration of CgA ranged from 0.59 to 9.95 pmol/mg protein before treatment and 6.80-0.00 pmol/mg protein after treatment. The CgA values decreased in 79.2% of children, and significantly more so in boys than in girls. Children with a high CFSS-DS score also had a high CgA level before treatment and the drop was relatively large compared to children with a low score. We attempted two different methods to measure the Aml level but both produced unstable results. It is concluded that the CgA in saliva might be a useful indicator of stress in children during dental treatment.

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