Expression of cyclooxygenase-2 and microsomal prostagalandin E synthase-1 by head and neck squamous cell carcinoma

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  • Kawata Ryo
    Department of Otolaryngology, Osaka Medical College

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Other Title
  • 頭頸部扁平上皮癌におけるシクロオキシゲナーゼ-2とプロスタグランジンE合成酵素の発現
Published
2011
DOI
  • 10.5648/jjiao.29.233
Publisher
JAPAN SOCIETY OF IMMUNOLOGY AND ALLERGOLOGY IN OTOLARYNGOLOGY

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Description

Our aim was to examine the expression of COX-2 and microsomal prostaglandin E synthase-1 (mPGES-1), and compare the results with clinical data. Expression of COX-1, COX-2, and mPGS-1 was evaluated by immunohistochemistry in head and neck squamous cell carcinoma (HNSCCs) from 25 patients and mRNA levels were determined by the quantitative reverse transcription polymerase chain reaction. COX-2 overexpression was noted in tumor cells from 19 of the 25 carcinoma patients and mPGES was expressed by tumor cells from 21 patients. Localization of COX-2 and mPGES-1 was very similar, and well-differentiated tumors showed stronger expression than poorly/moderately differentiated tumors. The COX-2/GAPDH and mPGES/GAPDH mRNA ratios were significantly higher in well-differentiated carcinomas and N0 patients. There was overexpression of COX-2 and its downstream enzyme mPGES-1, and their localization in tumor cells was similar, suggesting that these enzymes both play an important role in the development and proliferation of HNSCC. Furthermore, COX-2 and mPGES-1 were strongly expressed by well-differentiated carcinomas, suggesting their involvement in the differentiation of cancer.<br>

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