{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390001204361908352.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.2995/jacsurg.27.489"}},{"identifier":{"@type":"NAID","@value":"10031158802"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2013281848"}}],"dc:title":[{"@language":"en","@value":"Solitary fibrous tumor of the mediastinum: Report of a case"},{"@language":"ja","@value":"縦隔発生のSolitary Fibrous Tumorの1例"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"An 80-year-old woman was found to have an abnormal shadow on a routine chest radiograph. Subsequent chest CT demonstrated a round-shaped, 57×46-mm mass in the superior portion of the mediastinum and middle mediastinum, surrounded by the great vessels and trachea. FDG positron emission tomography (FDG-PET) revealed high-level FDG uptake by the tumor; malignant mediastinal tumor was suspected. She was referred to our hospital for diagnosis and treatment. Surgery using a limited upper sternotomy approach revealed a sessile tumor originating from the mediastinal soft tissue around the right brachiocephalic artery. We were unable to perform a combined resection of the brachiocephalic artery; thus, tumor resection was incomplete. Histopathologically, the tumor was diagnosed as benign SFT. Immunohistochemical examination revealed negativity for CD34, loss of bcl-2 expression, a high MIB-1 index, and positive p53 staining, and also suggested signs of malignancy. The patient elected not to receive any further surgery, and was simply followed up. The residual tumor had re-progressed 6 months postoperatively, and was then treated with conventional radiotherapy (60 Gy). The patient remains alive with disease 2 years postoperatively. SFT originating from the mediastinum is extremely rare, but may be more aggressive and malignant than SFT of the pleura. We report this case and provide a bibliographic review on the biological behavior and treatment of SFT originating from the mediastinum."},{"@language":"ja","@value":"症例は80歳，女性．胸部X線異常影を指摘され，胸部CT上，縦隔上部から中縦隔にわたって大血管と気管に囲まれる径57×46 mm大の類円形の腫瘤を認めた．FDG-PETでは高集積を示し，悪性縦隔腫瘍が疑われた．診断治療を目的に当科紹介となった．手術は胸骨部分切開でアプローチし，腕頭動脈周囲から広基性に発生する腫瘍に対し，腕頭動脈の合併切除は行わずに可及的に腫瘍を摘出した．良性の孤立性線維性腫瘍の病理組織診断であった．免疫組織化学的検討ではCD34陰性，bcl-2の染色性の低下，MIB-1高値，p53陽性などの悪性を示唆する所見も認めたが，再切除は希望されず，経過観察とした．術後5ヵ月で再増大し，放射線治療を行った．現在術後2年が経過し生存中である．縦隔発生のSFTは非常に稀であるが，胸膜発生のSFTと比べてより侵襲性で悪性度が高いとされる．生物学的特性と治療に関する文献的考察を加えて報告する．"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1420282801204493824","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"00817786"},{"@type":"NRID","@value":"1000000817786"},{"@type":"NRID","@value":"9000346916102"},{"@type":"NRID","@value":"9000411815055"},{"@type":"NRID","@value":"9000411813982"},{"@type":"NRID","@value":"9000414502448"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/00817786"}],"foaf:name":[{"@language":"en","@value":"Doi Ryoichiro"},{"@language":"ja","@value":"土肥 良一郎"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Chest Surgery, Oita Prefectural Hospital"},{"@language":"ja","@value":"大分県立病院呼吸器外科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410290697425805314","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Akamine Shinji"},{"@language":"ja","@value":"赤嶺 晋治"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Chest Surgery, Oita Prefectural Hospital"},{"@language":"ja","@value":"大分県立病院呼吸器外科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410009222449086592","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000017544818"}],"foaf:name":[{"@language":"en","@value":"Taniguchi Daisuke"},{"@language":"ja","@value":"谷口 大輔"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Chest Surgery, Oita Prefectural Hospital"},{"@language":"ja","@value":"大分県立病院呼吸器外科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410290697425805316","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Ikuta Yasushi"},{"@language":"ja","@value":"生田 安司"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Chest Surgery, Oita Prefectural Hospital"},{"@language":"ja","@value":"大分県立病院呼吸器外科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204754640514","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000006179620"}],"foaf:name":[{"@language":"en","@value":"Kondo Yoshiyuki"},{"@language":"ja","@value":"近藤 能行"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Pathology, Oita Prefectural Hospital"},{"@language":"ja","@value":"大分県立病院臨床検査部病理"}]},{"@id":"https://cir.nii.ac.jp/crid/1410290697425805313","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Urabe Shogo"},{"@language":"ja","@value":"卜部 省悟"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Pathology, Oita Prefectural Hospital"},{"@language":"ja","@value":"大分県立病院臨床検査部病理"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09190945"},{"@type":"LISSN","@value":"09190945"},{"@type":"EISSN","@value":"18814158"},{"@type":"NCID","@value":"AN10467885"}],"prism:publicationName":[{"@language":"en","@value":"The Journal of the Japanese Association for Chest Surgery"},{"@language":"ja","@value":"日本呼吸器外科学会雑誌"},{"@language":"en","@value":"Jpn J Chest Surg"},{"@language":"en","@value":"The Journal of the Japanese Associtation for Chest Surgery"},{"@language":"en","@value":"The Journal of the Japanese Association for Chest Surgery"},{"@language":"ja","@value":"日呼外会誌"}],"dc:publisher":[{"@language":"en","@value":"The Japanese Association for Chest Surgery"},{"@language":"ja","@value":"日本呼吸器外科学会"}],"prism:publicationDate":"2013","prism:volume":"27","prism:number":"4","prism:startingPage":"489","prism:endingPage":"494"},"reviewed":"false","url":[{"@id":"https://search.jamas.or.jp/link/ui/2013281848"}],"availableAt":"2013","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%E5%AD%A4%E7%AB%8B%E6%80%A7%E7%B7%9A%E7%B6%AD%E6%80%A7%E8%85%AB%E7%98%8D","dc:title":"孤立性線維性腫瘍"},{"@id":"https://cir.nii.ac.jp/all?q=%E7%B8%A6%E9%9A%94","dc:title":"縦隔"},{"@id":"https://cir.nii.ac.jp/all?q=solitary%20fibrous%20tumor","dc:title":"solitary fibrous tumor"},{"@id":"https://cir.nii.ac.jp/all?q=mediastinum","dc:title":"mediastinum"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011145780180480","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Solitary fibrous tumors of the pleura: clinicopathological and immunohistochemical 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operation."},{"@value":"緊急手術を要した巨大な胸部ｓｏｌｉｔａｒｙ　ｆｉｂｒｏｕｓ　ｔｕｍｏｒ合併ｖｏｎ　Ｒｅｃｋｌｉｎｇｈａｕｓｅｎ病患者の一例"}]},{"@id":"https://cir.nii.ac.jp/crid/1390282679338729216","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"A 3-ports-VATS resection of a solitary fibrous tumor in the mediastinum: A case report"},{"@language":"ja","@value":"３ポート胸腔鏡下手術で摘出した縦隔由来Ｓｏｌｉｔａｒｙ　Ｆｉｂｒｏｕｓ　Ｔｕｍｏｒの一例"}]},{"@id":"https://cir.nii.ac.jp/crid/1570009749366852608","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Solitary fibrous tumour : significance of p53 and CD34 immunoreactivity in its malignant transformation"}]},{"@id":"https://cir.nii.ac.jp/crid/1570009749366854272","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Solitary fibrous tumors of the pleura : clinicopathological and immunohistochemical 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A report of 14 cases"}]},{"@id":"https://cir.nii.ac.jp/crid/1572824499133961216","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Solitary fibrous tumor"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105975546482432","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Malignant solitary fibrous tumor with superior vena cava syndrome"}]},{"@id":"https://cir.nii.ac.jp/crid/1573950399040800256","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Solitary fibrous tumor (SFT)"}]},{"@id":"https://cir.nii.ac.jp/crid/1573950399040802560","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Solitary fibrous tumors of the pleura"}]},{"@id":"https://cir.nii.ac.jp/crid/1574231875583592448","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"胸膜の Localized (Solitary) fibrous tumor の病理"}]},{"@id":"https://cir.nii.ac.jp/crid/1574231875915382912","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@value":"孤立性線維性腫瘍および類似病変"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:1001954340"},{"@type":"CROSSREF","@value":"10.2995/jacsurg.27.489"},{"@type":"CIA","@value":"10031158802"}]}