書誌事項
- タイトル別名
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- <b>Histology and ultrastructure of bone </b><b>—microscopic aspects— </b>
- 公開日
- 2016
- DOI
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- 10.11154/pain.31.210
- 公開者
- 一般社団法人 日本疼痛学会
この論文をさがす
説明
<p>Bone is a supporting tissue consisting of a variety of bone cells (osteo blasts,osteoclasts, osteocytes), calcified bone matrix, blood vessels, nerves and so forth. Bone diseases — osteoporosis, bone fracture, arthritis, bone metastasis — often induce bone pain, presumably due to various kinds of nociceptors linked to the signaling in sensory nerves. Nociceptive pain in bone is caused by several stimuli of acid secreted by osteoclasts, physiochemical damaging on peripheral nerves, ATPs, prostaglandins, and so forth. However, precious knowledge on the biological function of bone cells may provide a clue for better understanding on the cellular mechanism of bone pain. In a physiological state, normal bone is always remodeled by balanced osteoclastic bone resorption and subsequent osteoblastic bone formation. Osteocytes connect to neighboring osteocytes and to osteoblasts on the bone surface by means of thin cytoplasmic processes that go through narrow passageways. i.e., osteocytic canaliculi, and thereby building functional syncytia referred to as osteocytic lacunar–canalicular system. Thus, osteocytes are at the center of bone turnover’s mainframe. In this review, we will introduce histological and ultrastructural aspects of bone cells, and give a rough outline of bone pain.</p>
収録刊行物
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- PAIN RESEARCH
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PAIN RESEARCH 31 (4), 210-219, 2016
一般社団法人 日本疼痛学会
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詳細情報 詳細情報について
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- CRID
- 1390001204367079168
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- NII論文ID
- 130005297224
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- ISSN
- 21874697
- 09158588
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可
