Age-Related Changes in the External and Midshaft Cross-Sectional Geometries of the Adult Recent Japanese Femur

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Other Title
  • 成人期近代日本人における大腿骨の加齢変化について
  • セイジン キキンダイ ニホンジン ニ オケル ダイタイコツ ノ カレイヘンカ ニ ツイテ
Published
2009
DOI
  • 10.1537/asj.117.99
Publisher
The Anthropological Society of Nippon

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Description

The periosteal dimensions, medullary area, and intra-cortical porosity of the femoral midshaft cross section were measured by using the recent Japanese materials (77 males, aged 20 to 81 years, and 39 females, aged 22 to 74 years), in order to further investigate age-related bone geometrical changes during adulthood. The midshaft cross sections were captured by micro-CT scanning. The samples were divided by age into three subgroups: YOUNG (20–49 years), MIDDLE (50–64 years), and OLD (65+ years). Differences among the subgroups were statistically examined by performing the t-test and Mann-Whitney U test. It was found that, in both sexes, there were no significant differences in the periosteal dimensions (the anteroposterior and mediolateral diameters and the total area) between YOUNG and MIDDLE and between YOUNG and OLD, indicating no femoral periosteal expansion during adulthood. In males there were no significant differences in the medullary area between YOUNG and MIDDLE and between YOUNG and OLD, while in females MIDDLE (P = 0.06) and OLD (P < 0.05) had the greater medullary area than YOUNG. The female medullary area tended to remain almost constant from their mid-20s to 40s and to increase remarkably from their 50s to 70s. These findings indicate a close relationship between menopause (decrease of female hormone) and increased endosteal resorption of femoral diaphysis. It was also found that in both sexes the intra-cortical porosity of older individuals tended to be greater than those of younger individuals, highly porous cross sections were observed particularly in females after the mid-30s. The results of the present study indicate that the functional adaptation compensating for age-related weakening of bone substance by periosteal expansion had not taken place in the recent Japanese femora, and that females have higher risk of age-related weakening of femoral diaphysis in comparison with males.<br>

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