{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390001204481212160.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.2325/jbcs.12.166"}},{"identifier":{"@type":"PMID","@value":"16110286"}},{"identifier":{"@type":"URI","@value":"http://www.springerlink.com/index/pdf/10.2325/jbcs.12.166"}},{"identifier":{"@type":"NAID","@value":"130004467392"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2006247828"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Postoperative Prognosis of Node-Negative Breast Cancers Predicted by Gene-Expression Profiling on a cDNA Microarray of 25,344 Genes"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"<b><i>Background</i>:</b> In Japan, postoperative relapse occurs within five years in 9.2 to 16% of patients whose breast cancers have not metastasized to lymph nodes at the time of initial surgery (node-negative, n0). Attempts to find molecular markers able to classify n0 breast cancers in terms of postoperative prognosis have not been successful.<br><b><i>Methods</i>:</b> To identify molecular indicators of prognosis for this type of cancer, we used a cDNA microarray consisting of 25,344 human genes to investigate expression profiles of 12 primary breast cancers from patients whose tumors recurred within five years after surgery (5Y-R) and 12 from patients who survived disease-free for more than five years (5Y-F).<br><b><i>Results</i>:</b> Sets of genes characterizing each group in terms of expression patterns in the tumors were selected by Mann-Whitney and random-permutation tests: these panels included 21 genes expressed highly in 5Y-R tumors than in 5Y-F tumors, and 37 with higher expression in the 5Y-F group than in the 5Y-R group.<br><b><i>Conclusions</i>:</b> We established a scoring system to prediction of postoperative prognosis which was 100% accurate as to the actual clinical outcomes of the 24 cases and therefore might be useful for predicting prognosis of n0 breast cancers in a clinical setting. The prognostic score system clearly separated the two groups without any overlap, and accurately predicted prognosis in 6 additional cases. Moreover, the extensive list of tumor-related genes identified in these experiments provides valuable information about progression of breast cancer and suggests potential target molecules for therapy of n0 breast cancers."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1030003658332914308","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90179945"},{"@type":"NRID","@value":"1000090179945"},{"@type":"NRID","@value":"9000259333682"},{"@type":"NRID","@value":"9000258013711"},{"@type":"NRID","@value":"9000006120242"},{"@type":"NRID","@value":"9000001635405"},{"@type":"NRID","@value":"9000256633375"},{"@type":"NRID","@value":"9000256624017"},{"@type":"NRID","@value":"9000003753664"},{"@type":"NRID","@value":"9000283216763"},{"@type":"NRID","@value":"9000010613905"},{"@type":"NRID","@value":"9000018529973"},{"@type":"NRID","@value":"9000256176347"},{"@type":"NRID","@value":"9000256623408"},{"@type":"NRID","@value":"9000257910056"},{"@type":"NRID","@value":"9000019060114"},{"@type":"NRID","@value":"9000014175028"},{"@type":"NRID","@value":"9000107385548"},{"@type":"NRID","@value":"9000021390724"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0090378"}],"foaf:name":[{"@language":"en","@value":"Chijiiwa Kazuo"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Surgery I, Division of Endocrine and Digestive System, Miyazaki Medical College"},{"@language":"ja","@value":"Department of Surgery I, Division of Endocrine and Digestive System, Miyazaki Medical College"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204481212160","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000257910055"}],"foaf:name":[{"@language":"en","@value":"Tsumagari Koji"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Molecular Biology, Institute of Gerontology, Nippon Medical School"},{"@language":"ja","@value":"Department of Molecular Biology, Institute of Gerontology, Nippon Medical School"},{"@language":"ja","@value":"Department of Surgery I, Division of Endocrine and Digestive System, Miyazaki Medical College"},{"@language":"en","@value":"Department of Surgery I, Division of Endocrine and Digestive System, Miyazaki Medical College"},{"@language":"ja","@value":"The Cancer Institute Hospital"},{"@language":"en","@value":"The Cancer Institute Hospital"}]},{"@id":"https://cir.nii.ac.jp/crid/1030848083583235074","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"10229338"},{"@type":"NRID","@value":"1000010229338"},{"@type":"NRID","@value":"9000240170378"},{"@type":"NRID","@value":"9000314791114"},{"@type":"NRID","@value":"9000002837798"},{"@type":"NRID","@value":"9000020296380"},{"@type":"NRID","@value":"9000257910699"},{"@type":"NRID","@value":"9000258562589"},{"@type":"NRID","@value":"9000015175291"},{"@type":"NRID","@value":"9000257909898"},{"@type":"NRID","@value":"9000257910545"},{"@type":"NRID","@value":"9000020120525"},{"@type":"NRID","@value":"9000398275336"},{"@type":"NRID","@value":"9000253337527"},{"@type":"NRID","@value":"9000256603233"},{"@type":"NRID","@value":"9000252850849"},{"@type":"NRID","@value":"9000257910058"},{"@type":"NRID","@value":"9000257910083"},{"@type":"NRID","@value":"9000303161578"},{"@type":"NRID","@value":"9000258091763"},{"@type":"NRID","@value":"9000409859348"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/mmakita59"}],"foaf:name":[{"@language":"en","@value":"Makita 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