プラセンタエキス中の活性成分の検討 炎症に対するプラセンタエキスの効果
書誌事項
- タイトル別名
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- Studies on Active-Ingredients of Placenta Extract. Effet of Placenta Extract on Inflammation.
- Effet of Placenta Extract on Inflammation
- 炎症に対するプラセンタエキスの効果
抄録
This study was aimed at examining the mechanism of anti-inflammatory actions of placenta extract. Placenta extract suppressed carrageenin edema. Carrageenin edema is a model of acute inflammation.<br>Carrageenin edema is mediated by serotonin, histamine, bradykinin, arachidonic acid prostaglandin E1 and prostglandin E2. We investigated the effect of placenta extract on rat hind paw edema induced by carrageenin edemas chemical mediators.<br>Placenta extract suppressed serotonin edema and histamine edema. Serotonin and histamine are regarded as allergy inducing factors. Moreover placenta extract had inhibitory effect on prostaglandins. Namely, placenta extract suppressed arachidonic acid-mediated edema and prostaglandin E2-mediated edema.<br>Arachidonic acid is a precursor of prostaglandin E2.<br>Arachidonic acid and prostaglandin E2 are regarded as edema enhancing factors. From these results, placenta extract had inhibitory effect on arachidonic acid and prostaglandin E2. Aspirin is a non-steroid anti-inflammtory drug. Non-steroid anti-inflammtory drugs have inhibitory effect of synthetic process from arachidonic acid to prostaglandin E2.<br>Differently from the mechanism of non-steroid anti-inflammatory drugs, placenta extract might have direct suppressive actions on prostaglandin E2. On the other hand, inflammatory exudates are an important response in inflammation. The post-treatment of placenta extract for 7 days showed anti-exudative actions. This experiment is a model of subacute inflammation. The above results suggested that anti-inflammatory actions of placenta extract are very particular.
収録刊行物
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- 日本化粧品技術者会誌
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日本化粧品技術者会誌 27 (3), 506-513, 1993
日本化粧品技術者会
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詳細情報 詳細情報について
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- CRID
- 1390001204500476288
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- NII論文ID
- 130004069749
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- ISSN
- 18844146
- 03875253
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可