圧力伝達の基礎的理論式に基づく湿潤粉体の特性解析

  • 大西 敬人
    大鵬薬品工業株式会社 製剤研究所
  • 綿野 哲
    大阪府立大学 大学院工学研究科 物質・化学系専攻 化学工学分野

書誌事項

タイトル別名
  • Analysis of Wet Powder Characteristics using Fundamental Numerical Model of Pressure Transmission
  • アツリョク デンタツ ノ キソテキ リロンシキ ニ モトズク シツジュン フンタイ ノ トクセイ カイセキ

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説明

In this study, compression test was applied to evaluate rheological characteristics of wet powder. Various quantities of moistened lactose monohydrate and microcrystalline cellulose were compressed in a cylinder. Relationships between compression transmission rate pT / P and dimensionless sample height H / D under various compression pressures P were fitted to a theoretical pressure transmission equation of pT / P =exp (-4μKH / D). As a result, high correlations were obtained between them, indicating that pressure transmission of wet powder behaved as the ideal condition. The stress applied to the cylinder inner wall during the compression test was measured using strain gauges attached to the cylinder wall and friction coefficient of the wall surface μ and Rankine coefficient K were calculated. Consequently, the behaviors of μ and K under various compression pressures, liquid contents and liquid viscosities were investigated. From these results, it was suggested that the method proposed in this study could estimate a state of the wet powder under pressure.

収録刊行物

  • 粉体工学会誌

    粉体工学会誌 49 (7), 528-537, 2012

    一般社団法人 粉体工学会

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