{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390001204517636736.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3805/jjes.6.232"}}],"dc:title":[{"@language":"en","@value":"Epileptiform response induced by acute or chronic intra-amygdaloid injection of bicuculline."},{"@value":"ビククリンのへん桃体注入によるてんかん様発作の発現について　　急性大量および少量反復投与による検討"}],"dcterms:alternative":[{"@value":"急性大量および少量反復投与による検討"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"In order to examine the hypothesis that dysfunction of GABAergic system in the amygdala is related to the development of amygdaloid seizure, an GABA antagonist, bicuculline methiodide, was injected into the amygda of rats. Chemitrodes for both micro-injection and EEG recording were implanted into the left basolateral amygdala. Two weeks after surgery, the animals received single intra-amygdaloid injection of a large dose of bicuculline (10nmol) or repeated (every fourth day) injections of a small dose of bicuculline (0.2or O.4nmol).<BR>The results were as follows. 1) In rats given a large dose of bicuculline, single injection elicited repetitive partial motor seizures which continued for over 60min. Finally, the epileptiform seizure developed to clonic generalized convulsions. 2) In rats given a small dose of bicuculline, repeated injections caused a progressive seizure development which was comparable to that seen in electrical kindling. The animals finally showed clonic generalized convulsions by the application of 5. 3 injections. 3) Histological examination showed prominent neuronal loss in some brain areas such as the bilateral hippocampi and pyriform cortices in the animals that had received the large dose of bicuculline. On the other hand, no histological changes specific to the antagonist injection was detected in the animals that had repeatedly received the small dose of the agent.<BR>The present experiment indicates that suppression of the GABAergic function in the amygdala causes epileptiform seizures and that chemical kidnling is readily induced by repeated injection of a small dose of bicuculline."},{"@value":"てんかん焦点におけるGABA神経系の役割を解明する目的で, ラットの扁桃体にGABA拮抗薬のビククリンを急性または慢性投与し, 得られたてんかん様反応について検討した。<BR>ビククリンの大量 (10nmol) を扁桃体に1回注入したところ, けいれん重積状態となり部分けいれんを繰り返した後, 全身けいれんが出現した。ビククリンの少量 (0.2または0.4nmol) を4日毎に注入したところ, 初期の投与ではけいれん発作は認めなかったが, 約5回の注入で全身けいれんが出現し化学キンドリングが作成された。組織学的には, 急性大量投与群にのみ海馬錐体細胞や梨状葉皮質などに顕著な神経細胞の変性脱落を認めた。<BR>以上より, 扁桃体に分布するGABA神経の機能的抑制が扁桃体焦点発作を誘発し, その反復が二次全般化を促したものと考察した。"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410001204517636736","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Uemura Shuji"},{"@language":"ja","@value":"植村 秀治"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Neuropsychiatry, Fukushima Medical College"},{"@language":"ja","@value":"福島県立医科大学神経精神医学"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09120890"},{"@type":"LISSN","@value":"09120890"},{"@type":"EISSN","@value":"13475509"}],"prism:publicationName":[{"@language":"en","@value":"Journal of the Japan Epilepsy Society"},{"@language":"ja","@value":"てんかん研究"},{"@language":"en","@value":"JJES"},{"@language":"en","@value":"J.Jpn.Epil.Soc."},{"@language":"ja","@value":"てんかん研究"}],"dc:publisher":[{"@language":"en","@value":"JAPAN EPILEPSY SOCIETY"},{"@language":"ja","@value":"一般社団法人 日本てんかん学会"}],"prism:publicationDate":"1988","prism:volume":"6","prism:number":"2","prism:startingPage":"232","prism:endingPage":"239"},"reviewed":"false","availableAt":"1988","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=bicuculline","dc:title":"bicuculline"},{"@id":"https://cir.nii.ac.jp/all?q=intra-amygdaloid%20injection","dc:title":"intra-amygdaloid injection"},{"@id":"https://cir.nii.ac.jp/all?q=chemical%20kindling","dc:title":"chemical kindling"},{"@id":"https://cir.nii.ac.jp/all?q=GABAergic%20system","dc:title":"GABAergic system"},{"@id":"https://cir.nii.ac.jp/all?q=epilepsy","dc:title":"epilepsy"}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0017330517"},{"@type":"CROSSREF","@value":"10.3805/jjes.6.232"}]}