ビオチン生産菌の生育ならびにビオチンの畜積に対するアデニンおよびアデノシンの作用

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タイトル別名
  • Effect of Adenine and Adenosine on the Biotin Production and the Growth of a Biotin-producing Bacterium
  • ビオチン セイサンキン ノ セイイク ナラビニ ビオチン ノ チクセキ ニ タイスル アデニン オヨビ アデノシン ノ サヨウ サイキンルイ ノ チクセキ スル ビオチン カッセイ ブッシツ ニ カンスル ケンキュウ 4

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The effect of adenine and adenosine on the biotin production and growth of a biotinproducing bacterium KY-21-1-25 was investigated.<br> The results are as follows;<br> (1) The effect of purine and pyrimidine bases and nucleosides on the growth of the bacterium was examined. The growth of the bacterium was strongly inhibited when adenine or adenosine was added to the medium. The others had no effect on the growth of the bacterium.<br> (2) The inhibitory activity of adenine sulfate at the concentration of 1mg/ml was completely reduced by the addition of thiamine, while that at over 2mg/ml was not reduced by thiamine alone.<br> (3) Adenine sulfate at any concentration had no effect on the growth of the bacterium in the medium containing yeast extract. The effective substances in the yeast extract were isolated and identified as guanine, uracil, uridine and cytidine respectively. These compounds were effective to reduce the inhibitory activity of adenine sulfate (4mg/ml) only when supplied with thiamine and biotin.<br> (4) The reversal effect of known purine and pyrimidine bases and nucleosides on the growth inhibition by adenine sulfate (4mg/ml) were examined using the medium containing thiamine and biotin. Uracil, uridine, cytidine, guanine, guanosine and xanthine were effective, hypoxanthine and orotic acid were slightly effective.<br> (5) It was concluded that the presence of thiamine and biotin with any one of purine or pyrimidine bases or nucleosides is necessary to reduce the growth inhibition by adenine sulfate (4mg/ml).<br> (6) The biotin production from dethiobiotin by the bacterium was accerelated by the addition of adenine or adenosine in the presence of yeast extract or iron salt.

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