Effects of Pantothenic Acid Supplementation on Adrenal Steroid Secretion from Male Rats

  • Jaroenporn Sukanya
    Department of Basic Veterinary Science, The United School of Veterinary Sciences, Gifu University Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology
  • Yamamoto Tatsuya
    Department of Basic Veterinary Science, The United School of Veterinary Sciences, Gifu University Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology
  • Itabashi Asuka
    Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology
  • Nakamura Katsuhiro
    Daiichi Fine Chemical Co.
  • Azumano Isao
    Daiichi Fine Chemical Co.
  • Watanabe Gen
    Department of Basic Veterinary Science, The United School of Veterinary Sciences, Gifu University Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology
  • Taya Kazuyoshi
    Department of Basic Veterinary Science, The United School of Veterinary Sciences, Gifu University Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology

この論文をさがす

抄録

The effects of pantothenic acid-supplementation on the adrenal secretion of corticosterone and progesterone in male rats were investigated using an in vitro cell culture system. Male rats at 21 d of age were given 0.03% pantothenic acid in their drinking water for 9 weeks. After 9 weeks of treatment, the animals were decapitated, and adrenal cells were cultured in the absence or presence of rat adrenocorticotropic hormone (ACTH; 10−15 to 10−10 M) and/or ovine prolactin (oPRL; 10−9 to 10−7 M) for 4 h. Adrenal cells in pantothenic acid-treated rats exhibited higher basal levels of corticosterone and progesterone than control rats. The response of ACTH and/or PRL on corticosterone and progesterone release was higher in the pantothenic acid-treated rats than in the control rats. In addition, PRL increased the stimulatory effect of ACTH-induced corticosterone secretion in both normal and pantothenic acid-treated rats. These results clearly demonstrated that pantothenic acid supplementation stimulates the ability of adrenal cells in male rats to secrete corticosterone and progesterone. Additionally, these results also showed that pantothenic acid supplementation induced adrenal hyperresponsiveness to ACTH stimulation, and PRL further stimulated adrenal sensitivity to ACTH.

収録刊行物

被引用文献 (4)*注記

もっと見る

参考文献 (32)*注記

もっと見る

詳細情報

問題の指摘

ページトップへ