{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390001204628362240.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.1248/bpb.32.1109"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"10235398"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/10235398"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I10235398"}},{"identifier":{"@type":"URI","@value":"http://www.jstage.jst.go.jp/article/bpb/32/6/32_6_1109/_pdf"}},{"identifier":{"@type":"PMID","@value":"19483325"}},{"identifier":{"@type":"NAID","@value":"130000117197"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2009325465"}}],"dc:title":[{"@language":"en","@value":"Methoxy- and Fluoro-chalcone Derivatives Arrest Cell Cycle Progression and Induce Apoptosis in Human Melanoma Cell A375"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Because of the lack of efficacious treatments for advanced melanoma, new approaches are necessary. Chalcones are contained in fruits and vegetables, and have been suggested to be cancer-preventive. In this study, effects of synthetic chalcone derivatives were investigated especially on the proliferation of human melanoma cells and peripheral blood mononuclear cells (PBMCs). Four out of the 12 synthetic chalcones: 4-trifluoromethyl-4′-methoxychalcone (CH-1), 4-trifluoromethyl-2′-methoxychalcone (CH-3), 3-trifluoromethyl-2′,4′-dimethoxychalcone (CH-4) and 3-trifluoromethyl-4′-methoxychalcone (CH-7) exhibited significant antiproliferative efficacies against the cultured cells of the human melanoma cell line A375. CH-1, CH-3, CH-4, and CH-7 induced cell cycle arrest at the S-G<sub>2</sub>/M phase within 24 h after the treatment. CH-3, CH-4, and CH-7 significantly activated caspase-3 at 12 h, subsequently induced apoptosis at 72 h. All chalcones inhibited concanavalin A-induced proliferation of PBMCs dose-dependently. Our results suggest that some methoxy- and/or fluoro-chalcones have antitumor efficacy by inducing apoptosis and the cell-cycle arrest."}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410001204628362244","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021929667"}],"foaf:name":[{"@language":"en","@value":"Henmi Kayo"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Clinical Pharmacology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204628362243","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021929669"}],"foaf:name":[{"@language":"en","@value":"Hiwatashi Yoko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Clinical Pharmacology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204628362240","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021929671"}],"foaf:name":[{"@language":"en","@value":"Hikita Eri"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Clinical Pharmacology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001204628362241","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000021929673"}],"foaf:name":[{"@language":"en","@value":"Toyama Naoya"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Clinical Pharmacology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences"}]},{"@id":"https://cir.nii.ac.jp/crid/1030003658353136130","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"90173252"},{"@type":"NRID","@value":"1000090173252"},{"@type":"NRID","@value":"9000240170377"},{"@type":"NRID","@value":"9000021816392"},{"@type":"NRID","@value":"9000391631745"},{"@type":"NRID","@value":"9000378081425"},{"@type":"NRID","@value":"9000006834540"},{"@type":"NRID","@value":"9000391619509"},{"@type":"NRID","@value":"9000365493258"},{"@type":"NRID","@value":"9000107395102"},{"@type":"NRID","@value":"9000363365744"},{"@type":"NRID","@value":"9000024814045"},{"@type":"NRID","@value":"9000021929674"},{"@type":"NRID","@value":"9000273030087"},{"@type":"NRID","@value":"9000408469290"},{"@type":"NRID","@value":"9000318587662"},{"@type":"NRID","@value":"9000253206968"},{"@type":"NRID","@value":"9000363365703"},{"@type":"NRID","@value":"9000240143452"},{"@type":"NRID","@value":"9000273012757"},{"@type":"NRID","@value":"9000405926376"},{"@type":"NRID","@value":"9000409009140"},{"@type":"NRID","@value":"9000273030058"},{"@type":"NRID","@value":"9000391628430"},{"@type":"NRID","@value":"9000365539755"},{"@type":"NRID","@value":"9000391623835"},{"@type":"NRID","@value":"9000375909155"},{"@type":"NRID","@value":"9000256471038"},{"@type":"NRID","@value":"9000273012710"},{"@type":"NRID","@value":"9000391624798"},{"@type":"NRID","@value":"9000253203144"},{"@type":"NRID","@value":"9000253205004"},{"@type":"NRID","@value":"9000404505418"},{"@type":"NRID","@value":"9000006691519"},{"@type":"NRID","@value":"9000253203748"},{"@type":"NRID","@value":"9000254710692"},{"@type":"NRID","@value":"9000252818996"},{"@type":"NRID","@value":"9000258206675"},{"@type":"NRID","@value":"9000256470836"},{"@type":"NRID","@value":"9000304619219"},{"@type":"NRID","@value":"9000273030091"},{"@type":"NRID","@value":"9000273012692"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/read0027216"}],"foaf:name":[{"@language":"en","@value":"Hirano Toshihiko"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Clinical Pharmacology, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"09186158"},{"@type":"EISSN","@value":"13475215"},{"@type":"NDL_BIB_ID","@value":"000000153250"},{"@type":"ISSN","@value":"09186158"},{"@type":"LISSN","@value":"09186158"},{"@type":"NCID","@value":"AA10885497"}],"prism:publicationName":[{"@language":"ja","@value":"Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ"},{"@language":"en","@value":"Biological and Pharmaceutical Bulletin"},{"@language":"en","@value":"Biological & Pharmaceutical Bulletin"},{"@language":"en","@value":"Biol. Pharm. Bull."},{"@language":"ja","@value":"Ｂｉｏｌ．　Ｐｈａｒｍ．　Ｂｕｌｌ．"}],"dc:publisher":[{"@language":"en","@value":"The Pharmaceutical Society of Japan"},{"@language":"ja","@value":"公益社団法人 日本薬学会"}],"prism:publicationDate":"2009","prism:volume":"32","prism:number":"6","prism:startingPage":"1109","prism:endingPage":"1113"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://id.ndl.go.jp/bib/10235398"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I10235398"},{"@id":"http://www.jstage.jst.go.jp/article/bpb/32/6/32_6_1109/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2009325465"}],"availableAt":"2009","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=melanoma","dc:title":"melanoma"},{"@id":"https://cir.nii.ac.jp/all?q=cell%20cycle","dc:title":"cell cycle"},{"@id":"https://cir.nii.ac.jp/all?q=apoptosis","dc:title":"apoptosis"},{"@id":"https://cir.nii.ac.jp/all?q=caspase-3","dc:title":"caspase-3"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1360011145543672576","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"SYSTEMIC CHIMERISM IN SEX-MISMATCHED LIVER TRANSPLANT RECIPIENTS DETECTED BY FLUORESCENCE IN SITU HYBRIDIZATION"}]},{"@id":"https://cir.nii.ac.jp/crid/1360292620340265088","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Implications of tissue transglutaminase expression in malignant melanoma"}]},{"@id":"https://cir.nii.ac.jp/crid/1360303973288668800","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Gramicidin as a potential immunosuppressant for organ transplantation: suppression of human lymphocyte blastogenesis in vitro and prolongation of heart allograft survival in the rat."}]},{"@id":"https://cir.nii.ac.jp/crid/1360567185718633728","@type":"Article","resourceType":"学術雑誌論文(journal article)","relationType":["isReferencedBy"],"jpcoar:relatedTitle":[{"@value":"Antiproliferative and anti-invasive effects of inorganic and organic arsenic compounds on human and murine melanoma cells <i>in vitro</i>"}]},{"@id":"https://cir.nii.ac.jp/crid/1360855568579084288","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"2′,4′,6′-Tris(methoxymethoxy) chalcone protects against trinitrobenzene sulfonic acid-induced colitis and blocks tumor necrosis factor-α-induced intestinal epithelial inflammation via heme oxygenase 1-dependent and independent pathways"}]},{"@id":"https://cir.nii.ac.jp/crid/1361137046291012224","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Synthesis and biological evaluation of chalcones and their derived pyrazoles as potential cytotoxic agents"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699994123238528","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Structure−Activity Relationships of Methoxychalcones as Inducers of Heme Oxygenase-1"}]},{"@id":"https://cir.nii.ac.jp/crid/1361699995789383936","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Caspases – controlling intracellular signals by protease zymogen activation"}]},{"@id":"https://cir.nii.ac.jp/crid/1361981468989880064","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Synthetic and biological activity evaluation studies on novel 1,3-diarylpropenones"}]},{"@id":"https://cir.nii.ac.jp/crid/1362262946139100416","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Chalcones and their Potential Role in Inflammation"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544418477449728","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Cell Death"}]},{"@id":"https://cir.nii.ac.jp/crid/1362544420131291520","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Linked Parallel Synthesis and MTT Bioassay Screening of Substituted Chalcones"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825896105334656","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Phloretin-induced apoptosis in B16 melanoma 4A5 cells by inhibition of glucose transmembrane transport"}]},{"@id":"https://cir.nii.ac.jp/crid/1362825896142397312","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Statistical profiles of malignant melanoma and other skin cancers in Japan: 2007 update"}]},{"@id":"https://cir.nii.ac.jp/crid/1363388845890951680","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"DTIC and combination therapy for melanoma: III. 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