Intravenous thrombolysis with rt-PA in a cardiogenic cerebral embolism patient during anticoagulant therapy with rivaroxaban

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Other Title
  • リバーロキサバン内服中の脳梗塞再発に対しrt-PA 静注療法を施行した1 例
Published
2014
DOI
  • 10.3995/jstroke.36.82
Publisher
The Japan Stroke Society

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We report a case of ischemic stroke during anticoagulant therapy with rivaroxaban who underwent intravenous thrombolysis with rt-PA. A 78-year-old-woman presenting right hemiparesis and motor aphasia was admitted to our hospital. MRI (DWI) showed a hyper-intensity area in the left frontal lobe. Since more than 18 hours had passed after last intake of rivaroxaban and the prothrombin time was 91%, so its blood concentration and anticoagulant effect were assumed low. Therefore rt-PA was administered 3 hours and 40 minutes after the onset. Right hemiparesis was improved and she was discharged with a mild speech disturbance. Safety of rt-PA administration might be assessed by elapsed time from last intake of rivaroxaban.

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