リポソームとDDS  ポリエチレングリコール表面修飾リポソームの繰り返し投与時に発現するaccelerated blood clearance(ABC)現象

  • 石田 竜弘
    徳島大学大学院ヘルスバイオサイエンス研究部統合医療創生科学部門薬物機能制御学講座薬物動態学分野
  • 際田 弘志
    徳島大学大学院ヘルスバイオサイエンス研究部統合医療創生科学部門薬物機能制御学講座薬物動態学分野

書誌事項

タイトル別名
  • Accelerated blood clearance of PEGylated liposomes after repeated injection
  • Accelerated blood clearance of PEGylated liposomes after repeated injection
  • ポリエチレングリコール表面修飾リポソームの繰り返し投与時に発現するaccelerated blood clearance(ABC)現象

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抄録

We and a Dutch group have recently reported the accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes, that is the enhanced accumulation of PEGylated liposomes in liver and consequently rapidly cleared the liposomes from blood circulation. The phenomenon is a general characteristic of liposomes and the induction of the phenomenon depends on the physicochemical property and dose of liposomes and animal species. In addition, our study indicated that the IgM secreted in response to first dose is involved in the occurrence of the phenomenon. In this article, our and a Dutch group's recent results related to the ABC phenomenon were described.

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