The Effects of Aeronic Exercise on Endothelium-dependent Vasodilation in Humans.

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  • GOTO Chikara
    Program in Physical Therapy Health Sciences, School of Medicine, Hiroshima University
  • HIGASHI Yukihito
    First Department of Internal Medicine, School of Medicine, Hiroshima University
  • SASAKI Shouta
    First Department of Internal Medicine, School of Medicine, Hiroshima University
  • NAKAGAWA Keigo
    First Department of Internal Medicine, School of Medicine, Hiroshima University
  • KIMURA Masasi
    First Department of Internal Medicine, School of Medicine, Hiroshima University
  • NOMA Kensuke
    First Department of Internal Medicine, School of Medicine, Hiroshima University
  • HARA Keiko
    First Department of Internal Medicine, School of Medicine, Hiroshima University
  • CHAYAMA Kazuaki
    First Department of Internal Medicine, School of Medicine, Hiroshima University
  • KAWAMURA Mitsutoshi
    Institute of Health Sciences, School of Medicine, Hiroshima University
  • NARA Isao
    Institute of Health Sciences, School of Medicine, Hiroshima University

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Other Title
  • 有酸素運動が血管内皮機能へ及ぼす影響
  • ユウサンソ ウンドウ ガ ケッカン ナイヒ キノウ エ オヨボス エイキョウ

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The purpose of this study was to determine the effects of aerobic exercise on endothelium-dependent vasodilation in humans. We evaluated the forearm blood flow (FBF) response to acetylcoline (ACh), an endothelium-dependent vasodilator, and isosorbide dinitrate (ISDN), an endothelium-independent vasodilator, before and after exercise (bicycle ergometers, 30 min, 5 to 7 times per week, for 12 weeks, 50%Vo2max) in healty young men (n=8, mean age: 27 ± 3 yr). FBF was measured using a mercury-filled Silastic strain-gauge plethysmograpy. Twelve weeks of exercise significantly augmentated ACh-induced vasodilation (7.5 ± 2.4 to 11.4 ± 5.8 ml/min/100 ml tissue, p<0.05). Aerobic exercise didn't alter ISDN-induced vasodilation. Administration of NG-monomethyl-L-arginin (L-NMMA), a nitric oxide synthase inhibitor, abolished exercise-induced augmentation of the FBF response to ACh. These findings suggest that aerobic exercise augments endothelium-dependent vasodilation in humans through the increased nitric oxide production.<br>

Journal

  • Rigakuryoho Kagaku

    Rigakuryoho Kagaku 17 (2), 87-91, 2002

    The Society of Physical Therapy Science

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