An Operable Case of Squamous Cell Carcinoma of the Lung with Elevated Serum Creatine Kinase Level

Toda Arinobu, Matsumoto Isao, Oda Makoto, Watanabe Go

doi:10.2482/haigan.50.162

Background. Elevated serum creatine kinase (CK) is a potential tumor marker in patients with lung cancer. Case. A 61-year-old woman visited our hospital because of an abnormal shadow detected on her chest X-ray film during a routine medical checkup. On admission, her CK level was elevated, but with a normal pattern of distribution of the CK isoenzymes. A diagnosis of neuromuscular disease was excluded on clinical and neurophysiological examinations. Chest CT showed an irregularly-shaped mass in S¹⁰ of the left lung. Sputum cytology and bronchial brushing cytology confirmed a diagnosis of squamous cell carcinoma (cT2N0M0 stage IB), and a left lower lobectomy with lymph node dissection was performed. Immunohistochemistry revealed focal staining of the tumor with both anti-CK-MM and anti-CK-BB antibodies. At the time of writing, 5 years after the operation, the patient remains alive without recurrence. Conclusion. We concluded that the lung tumor cells in this patient produced CK and that elevation of the serum CK level may serve as a marker of tumor recurrence.<br>

An Operable Case of Squamous Cell Carcinoma of the Lung with Elevated Serum Creatine Kinase Level

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