書誌事項
- タイトル別名
-
- Genetic Mapping of Candidate Gene Influencing the Defect of Tooth in EL Congenic Mice
この論文をさがす
抄録
EL/Sea mice have 100% incidence of the defect of the third molars (M3), and are used as an animal model for the study of missing teeth.<BR>We previously have reported that a region between 123.1 Mega base pair (Mbp) and 136.9 Mbp in chromosome 3 was involved in the defect of M3 of EL, and named this gene absence of the third molars (am3).<BR>The purpose of the present study is to narrow the am3 region causing the absence of M3 in EL/Sea mice, and to identify the major candidate gene.<BR>For this reason we generated EL/Sea congenic mice with the am3 region in which the restricted interval of chromosome 3 was replaced by a MSM/Msf-derived homologue.<BR>We also examined the location of chromosomal recombination in the am3 region by newly produced DNA maker.<BR>By comparing genotypes and phenotypes of EL congenic mice, we clearly mapped the am3 locus within an approximately 1000 kbp region between 130.7 Mbp and 131.7 Mbp.<BR>This region includes 5 genes, Lefl, Hadh, Cyp2u1, Sgms2 and Papss 1 as candidate genes for am3.
収録刊行物
-
- The Japanese Journal of Pediatric Dentistry
-
The Japanese Journal of Pediatric Dentistry 46 (5), 511-516, 2008
The Japanese Society of Pediatric Dentistry
- Tweet
キーワード
詳細情報
-
- CRID
- 1390001204686614784
-
- NII論文ID
- 10027487069
-
- NII書誌ID
- AN00116228
-
- ISSN
- 05831199
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- CiNii Articles
- KAKEN
-
- 抄録ライセンスフラグ
- 使用不可