The evaluation of human papillomavirus DNA testing for mass screening of cervical lesions

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  • TANGO Masahiro
    Member of the Kanazawa City Cervical Cancer Screening Research Team Department of Obstetrics and Gynecology, Kanazawa Medical Center
  • KANAYA Taro
    Member of the Kanazawa City Cervical Cancer Screening Research Team Department of Obstetrics and Gynecology, Kanazawa Medical Center
  • HASHIMOTO Shigeru
    Member of the Kanazawa City Cervical Cancer Screening Research Team Department of Obstetrics and Gynecology, Kanazawa City Hospital
  • MAEKAWA Nobumasa
    Member of the Kanazawa City Cervical Cancer Screening Research Team
  • UKITA Toshihiko
    Member of the Kanazawa City Cervical Cancer Screening Research Team
  • KOYAMA Nobu
    Member of the Kanazawa City Cervical Cancer Screening Research Team
  • OKAMURA Makoto
    Member of the Kanazawa City Cervical Cancer Screening Research Team
  • INOUE Masaki
    Member of the Kanazawa City Cervical Cancer Screening Research Team Department of Obstetrics and Gynecology, School of Medicine, Kanazawa University

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  • 子宮頸がん検診における HPV 検査の導入とその有用性

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Abstract

Objectives: Human papillomavirus (HPV) DNA testing was done as an adjunct to cervical cytology to evaluate its usefulness in cervical cancer screening.<br>Study Design: Between May 2004 and March 2006, 33790 women living in Kanazawa City were screened based on Bethesda cytological classification. In cases with ASC (ASC-US and ASC-H), HPV DNA testing was done using Hybrid Capture-II. Cytology-ASC-and HPV-positive women underwent colposcopy to determine the histological diagnosis.<br>Results: Of these 33790, 1565 (4.6%) had ASC cytology. HPV DNA was positive in 221 (14.1%) of the 1565. Of these 221, 169 (76.5%) underwent biopsy. Of these 169, 27 had disease exceeding CIN 2.<br>Conclusions: HPV DNA testing, combined with cytology significantly improved CIN screening efficacy and avoided unnecessary biopsies.

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