Postoperative Analgesia and Recovery with IV-PCA Morphine and Diclofenac Suppository after Spinal Surgery
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This study was designed to examine the efficacy of combination therapy with intravenous morphine and diclofenac suppository after spinal surgeries. Following informed consent, 32 patients undergoing elective spinal surgeries were studied. They were randomly assigned, according to the postoperative analgesic regimen, to either the morphine (M) group (n=16), who received IV-PCA morphine alone, or the morphine+diclofenac (M+D) group (n=16), who received, in addition to morphine PCA, diclofenac suppositories 50 mg every 6 h starting immediately before surgical incision for 48 h. Postoperative analgesic profiles, extent of side effects, and other complications were assessed using unpaired t-test, chi-squared test and Mann-Whitney U-test, with P < 0.05 being significant. Median pain score was lower in the M+D group. Postoperative morphine consumption and the extent of side effects (nausea/vomiting and sedation) were less in the M+D group. Time to first oral intake and bowel movement was shorter in the M+D group. Our data justify the combination therapy using IV-PCA morphine and diclofenac suppository for post-spinal surgery analgesia and recovery.
- THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA
THE JOURNAL OF JAPAN SOCIETY FOR CLINICAL ANESTHESIA 32 (4), 541-547, 2012
THE JAPAN SOCIETY FOR CLINICAL ANESTHESIA