Apoprotein E-rich high density lipoprotein in liver disease and cholestasis

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  • MIYATA Yasuji
    The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University
  • KOGA Shunichi
    The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University
  • IBAYASHI Hiroshi
    The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University

Bibliographic Information

Other Title
  • 肝胆道疾患患者における高比重リポたんぱく異常について　　とくにアポたんぱくＥの検討
  • カン タンドウ シッカン カンジャ ニ オケル コウ ヒジュウ リポ タンパク

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Description

Content of apoprotein E (apo E) in high density lipoprotein (HDL) was examined in hepatobiliary disease by semiquantitative method of SDS polyacrylamide gel electrophoresis.<BR>Abnormal increase of HDL apo E was observed in 10 of 20 with acute hepatitis, 2 of 5 with hepatocellular carcinoma and 2 of 3 with obstructive jaundice. Manifest HDL apo E was observed in patients with severe form of acute hepatitis ans in terminal stage of hepatocellular carcinoma, which was accompanied with marked decrease of HDL, hyperbilirubinemia and the elevation of alkaline phosphatase activity.<BR>Apo E content in HDL from patients with chronic hepatitis and compensated cirrhosis were almost normal. The appearance of apo E-rich high density lipoprotein in patients with severe liver disease and cholestasis suggests abnormalities of nascent HDL metabolism due to decreased LCAT activity. But mechanisms which may contribute appearance of apo E-rich HDL in patients with cholestasis need farther investigation.

Journal

  • Kanzo

    Kanzo 24 (2), 167-173, 1983

    The Japan Society of Hepatology

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