A case of hepatitis hard to diagnose autoimmune hepatitis or primary biliary cirrhosis-autoimmune hepatitis overlap syndrome
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- Tomizawa Minoru
- Department of Gastroenterology, National Hospital Organization Shimoshizu Hospital
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- Shinozaki Fuminobu
- Department of Radiology, National Hospital Organization Shimoshizu Hospital
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- Fugo Kazunori
- Department of Neurology, National Hospital Organization Shimoshizu Hospital
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- Motoyoshi Yasufumi
- Department of Molecular Pathology, Chiba University Graduate School of Medicine
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- Sugiyama Takao
- Department of Rheumatology, National Hospital Organization Shimoshizu Hospital
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- Yamamoto Shigenori
- Department of Pediatrics, National Hospital Organization Shimoshizu Hospital
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- Kishimoto Takashi
- Department of Neurology, National Hospital Organization Shimoshizu Hospital
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- Sueishi Makoto
- Department of Rheumatology, National Hospital Organization Shimoshizu Hospital
Bibliographic Information
- Other Title
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- ステロイド剤が著効したPBC-AIHが疑われた1例
- 症例報告 ステロイド剤が著効したPBC-AIHが疑われた1例
- ショウレイ ホウコク ステロイドザイ ガ チョコウシタ PBC-AIH ガ ウタガワレタ 1レイ
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Abstract
A 71-year-old female visited our hospital with general malaise and appetite loss, and showed jaundice. Immediately she admitted for further investigation. She was negative for viral markers for hepatitis B or C virus. Anti-mitochondrial antibody-M2 was 44.9. International Autoimmune Hepatitis Group Scoring System and Simplified Diagnostic Criteria for Autoimmune Hepatitis were 13 and 5, respectively. Her prothrombin time-international normalized ratio (PT-INR) and total bilirubin (T-Bil) were 1.31 and 26 mg/dl, respectively. Computed tomography showed ascites. She was suspected of probable autoimmune hepatitis (AIH) or primary biliary cirrhosis -AIH overlap syndrome. She would deteriorate without any treatment. Prednisolone was administered intravenously on 26 days of admission. Her T-Bil and ALT dramatically decreased and reached below normal limits on day 66 and 59 days of admission. PT-INR recovered and ascites disappeared. She discharged on 73 days of admission.
Journal
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- Kanzo
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Kanzo 55 (6), 360-366, 2014
The Japan Society of Hepatology