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A case of hepatitis hard to diagnose autoimmune hepatitis or primary biliary cirrhosis-autoimmune hepatitis overlap syndrome

  • Tomizawa Minoru
    Department of Gastroenterology, National Hospital Organization Shimoshizu Hospital
  • Shinozaki Fuminobu
    Department of Radiology, National Hospital Organization Shimoshizu Hospital
  • Fugo Kazunori
    Department of Neurology, National Hospital Organization Shimoshizu Hospital
  • Motoyoshi Yasufumi
    Department of Molecular Pathology, Chiba University Graduate School of Medicine
  • Sugiyama Takao
    Department of Rheumatology, National Hospital Organization Shimoshizu Hospital
  • Yamamoto Shigenori
    Department of Pediatrics, National Hospital Organization Shimoshizu Hospital
  • Kishimoto Takashi
    Department of Neurology, National Hospital Organization Shimoshizu Hospital
  • Sueishi Makoto
    Department of Rheumatology, National Hospital Organization Shimoshizu Hospital

Bibliographic Information

Other Title
  • ステロイド剤が著効したPBC-AIHが疑われた1例
  • 症例報告 ステロイド剤が著効したPBC-AIHが疑われた1例
  • ショウレイ ホウコク ステロイドザイ ガ チョコウシタ PBC-AIH ガ ウタガワレタ 1レイ

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Abstract

A 71-year-old female visited our hospital with general malaise and appetite loss, and showed jaundice. Immediately she admitted for further investigation. She was negative for viral markers for hepatitis B or C virus. Anti-mitochondrial antibody-M2 was 44.9. International Autoimmune Hepatitis Group Scoring System and Simplified Diagnostic Criteria for Autoimmune Hepatitis were 13 and 5, respectively. Her prothrombin time-international normalized ratio (PT-INR) and total bilirubin (T-Bil) were 1.31 and 26 mg/dl, respectively. Computed tomography showed ascites. She was suspected of probable autoimmune hepatitis (AIH) or primary biliary cirrhosis -AIH overlap syndrome. She would deteriorate without any treatment. Prednisolone was administered intravenously on 26 days of admission. Her T-Bil and ALT dramatically decreased and reached below normal limits on day 66 and 59 days of admission. PT-INR recovered and ascites disappeared. She discharged on 73 days of admission.

Journal

  • Kanzo

    Kanzo 55 (6), 360-366, 2014

    The Japan Society of Hepatology

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