{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390001204848871808.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.3919/jjsa.69.1024"}},{"identifier":{"@type":"URI","@value":"http://www.jstage.jst.go.jp/article/jjsa/69/5/69_5_1024/_pdf"}},{"identifier":{"@type":"NAID","@value":"130004516948"}},{"identifier":{"@type":"NAID","@value":"10024145573"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2008213343"}}],"dc:title":[{"@language":"en","@value":"TWO CASES OF GRANULOMATOUS MASTITIS"},{"@language":"ja","@value":"肉芽腫性乳腺炎の２例"}],"dc:language":"ja","description":[{"type":"abstract","notation":[{"@language":"en","@value":"Case 1 : A 35-year-old woman presented with an 8×5cm mass in the lower inner quadrant of her left breast accompanied by skin redness and tenderness. Purulent nipple discharge, whose culture and cytology showed no microorganisms and no malignant cells, was also observed. Histological diagnosis of the induration was mastitis. As the induration and purulent discharge persisted despite 2 months of antibiotics and drainage therapy, the induration was extirpated. After that, the patient recovered. Case 2 : A 32-year-old woman presented with a 6×6cm mass and skin redness in the upper half of her left breast. A core needle biopsy specimen showed chronic inflammation without any malignant findings. Antibiotics and surgical drainage were performed, but those were not effective. As purulent discharge (no microorganisms) and the local tumor persisted, 3 months later the whole tumor was removed, and the patient recovered. Histologically widespread inflammation extended along the mammary ducts and multinucleated giant cells were seen in both cases. Histological diagnosis was granulomatous mastitis.<BR>There have been 42 Japanese cases of granulomatous mastitis including our two patients. Various effective treatments have been reported including steroids and Seton method, but there is no established treatment at present. So more research is needed regarding this disease."},{"@language":"ja","@value":"症例1は35歳，女性．左乳房B領域に8×5cm大の皮膚発赤と圧痛を伴う硬結を認めた．乳頭から膿汁流出も認めた．分泌物の培養，細胞診と硬結部の針生検では，乳腺炎の診断で細菌は認めなかった．抗生剤や切開排膿で経過をみたが，硬結は残存し膿汁流出が続いたため，2カ月後硬結部位を摘出し完治した．症例2は，32歳，女性．左AC領域に径6×6cm大の発赤を伴う硬結を認めた．針生検の結果は，慢性炎症で悪性所見は認めなかった．抗生剤および発赤部位の切開排膿で経過をみたが，膿の流出は続き（培養陰性），硬結も残存したため，3カ月後硬結部位を摘出し完治した．いずれも病理では乳管に沿って広範囲に炎症像を認め，多核巨細胞もみられ，肉芽腫性乳腺炎と診断された．肉芽腫性乳腺炎の本邦論文報告は，自験例を加えて42例であった．ステロイドやSeton法などの有効例も報告されているが，治療指針に確立されたものはなく，さらなる症例の集積が望まれる．"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1410853647209650433","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000002949566"},{"@type":"NRID","@value":"9000258107399"}],"foaf:name":[{"@language":"en","@value":"TAMURA Hikaru"},{"@language":"ja","@value":"田村 光"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Surgery, Ohtawara Red Cross Hospital"},{"@language":"ja","@value":"大田原赤十字病院外科"}]},{"@id":"https://cir.nii.ac.jp/crid/1410853647209650432","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000006779639"},{"@type":"NRID","@value":"9000258107400"}],"foaf:name":[{"@language":"en","@value":"OKADA Masaki"},{"@language":"ja","@value":"岡田 真樹"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Surgery, Haga Red Cross Hospital"},{"@language":"ja","@value":"芳賀赤十字病院"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"13452843"},{"@type":"EISSN","@value":"18825133"},{"@type":"NCID","@value":"AA11189709"}],"prism:publicationName":[{"@language":"en","@value":"Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)"},{"@language":"ja","@value":"日本臨床外科学会雑誌"},{"@language":"en","@value":"Nihon Rinsho Geka Gakkai Zasshi (J Jpn Surg Assoc)"},{"@language":"en","@value":"J Jpn Surg Assoc"},{"@language":"en","@value":"J. Jpn. Surg. Assoc."},{"@language":"ja","@value":"日臨外会誌"},{"@language":"en","@value":"Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association)"},{"@language":"ja","@value":"日本臨床外科学会雑誌"}],"dc:publisher":[{"@language":"en","@value":"Japan Surgical Association"},{"@language":"ja","@value":"日本臨床外科学会"}],"prism:publicationDate":"2008","prism:volume":"69","prism:number":"5","prism:startingPage":"1024","prism:endingPage":"1028"},"reviewed":"false","url":[{"@id":"http://www.jstage.jst.go.jp/article/jjsa/69/5/69_5_1024/_pdf"},{"@id":"https://search.jamas.or.jp/link/ui/2008213343"}],"availableAt":"2008","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=%E8%82%89%E8%8A%BD%E8%85%AB%E6%80%A7%E4%B9%B3%E8%85%BA%E7%82%8E","dc:title":"肉芽腫性乳腺炎"},{"@id":"https://cir.nii.ac.jp/all?q=%E3%82%B9%E3%83%86%E3%83%AD%E3%82%A4%E3%83%89","dc:title":"ステロイド"},{"@id":"https://cir.nii.ac.jp/all?q=Seton%E6%B3%95","dc:title":"Seton法"}],"relatedProduct":[{"@id":"https://cir.nii.ac.jp/crid/1362262945053863296","@type":"Article","relationType":["references"],"jpcoar:relatedTitle":[{"@value":"Granulomatous mastitis diagnosed by core-needle biopsy and successfully treated with corticosteroid therapy: A case 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