A prospective controlled study of Sairei-to in childhood IgA nephropathy with focal/minimal mesangial proliferation.
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- YOSHIKAWA Norishige
- Faculty of Health Science, Kobe University School of Medicine
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- ITO Hiroshi
- National Children's Hospital
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- SAKAI Tadasu
- Kidney Center, Kitasato University Hospital
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- TAKEKOSHI Yasuo
- Department of Pediatrics, Hokkaido University
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- HONDA Masataka
- Division of Nephrology, Tokyo Metropolitan Children's Hospital
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- AWAZU Midori
- Department of Pediatrics, Keio University
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- ITO Katsumi
- Department of Pediatric Nephrology, Tokyo Women's Medical College
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- IITAKA Kikuo
- Kidney Center, Kitasato University Hospital
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- KOITABASHI Yasushi
- Department of Pediatrics , St. Marianna Medical College
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- YAMAOKA Kanji
- Department of Pediatrics, Osaka University
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- NAKAGAWA Kimiko
- Department of Pediatrics, Osaka Medical Center Research Institute for Maternal and Child
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- NAKAMURA Hajime
- Department of Pediatrics, Kobe University School of Medicine
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- MATSUYAMA Souichirou
- Kobe Children's Hospital
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- SEINO Yoshiki
- Department of Pediatrics, Okayama University
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- TAKEDA Nobuaki
- Department of Pediatrics, Kurashiki Central Hospital
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- HATTORI Shinzaburou
- Department of Pediatrics, Kumamoto University
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- NINOMIYA Makoto
- Department of Pediatrics, Kagoshima City Hospital
Bibliographic Information
- Other Title
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- 巣状・微小メサンギウム増殖を示す小児期ＩｇＡ腎症における讐崇ける柴苓湯治療のプロスペクティブコントロールスタディ
Description
To determine the effect of the Chinese herbal medicine, Sairei-to (TJ-114) in children with newly diagnosed IgA nephropathy showing focal/minimal mesangial proliferation, we undertook a prospective controlled study. One hundred and one patients were randomly assigned to receive Sairei-to for 2 years (group 1) or no drug for 2 years (group 2) . Forty-six of the 50 patients in group 1 and 48 of the 51 patients in group 2 completed their trial. At entry, the two groups of patients did not differ in their clinical, laboratory and pathologic findings. At the end of the trial, urinary protein excretion and hematuria were significantl y reduced in group 1, but were unchanged in group 2. Twenty-one group 1 patients (46%) had normal urine, but only 5 group 2 patients (10%) had normal urine at the end of the trial (p<0.001). Blood pressure and creatinine clearance were normal at the end of the trial in all but one group 2 patient, who developed chronic renal failure. The present study demonstrates that 2-year Sairei-to treatment early in the course of disease is effective in children with IgA nephropathy showing focal/minimal mesangial proliferation.
Journal
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- The Japanese Journal of Nephrology
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The Japanese Journal of Nephrology 39 (5), 503-506, 1997
Japanese Society of Nephrology
