Anti-neuronal Antibodies in Acute Pandysautonomia

  • Matsui Naoko
    Department of Neurology, Institute of Health Bioscience, Graduate School of Medicine, University of Tokushima
  • Mitsui Takao
    Department of Neurology, Institute of Health Bioscience, Graduate School of Medicine, University of Tokushima Department of Neurology, Tokushima National Hospital, National Hospital Organization
  • Ohshima Yasushi
    Department of Medicine and Bioregulatory Sciences, Institute of Health Bioscience, Graduate School of Medicine, University of Tokushima
  • Yokoi Kenji
    Department of Medicine and Bioregulatory Sciences, Institute of Health Bioscience, Graduate School of Medicine, University of Tokushima
  • Kunishige Makoto
    Department of Medicine and Bioregulatory Sciences, Institute of Health Bioscience, Graduate School of Medicine, University of Tokushima
  • Yagi Fumikazu
    Department of Medicine and Bioregulatory Sciences, Institute of Health Bioscience, Graduate School of Medicine, University of Tokushima
  • Vernino Steven
    Department of Neurology, University of Texas Southwestern Medical Center
  • Matsumoto Toshio
    Department of Medicine and Bioregulatory Sciences, Institute of Health Bioscience, Graduate School of Medicine, University of Tokushima
  • Kaji Ryuji
    Department of Neurology, Institute of Health Bioscience, Graduate School of Medicine, University of Tokushima

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抄録

We encountered two patients with acute pandysautonomia who subacutely exhibited extensive autonomic dysfunction after antecedent infections. Although these patients had been suffering from autonomic disturbance for several months, they both had a good clinical course after plasma exchange and intravenous immunoglobulin therapy. Thin-layer chromatography (TLC)-immunostaining did not demonstrate any antibodies against gangliosides, but immunoblot analysis showed antibodies against a neuroblastoma cell line, SH-SY5Y, in serum samples. Furthermore, ganglionic acetylcholine receptor autoantibodies were detected in one patient. These findings suggest that neuronal antibodies against the autonomic nervous system play an important role in the pathogenesis of acute pandysautonomia.<br>

収録刊行物

  • Internal Medicine

    Internal Medicine 49 (1), 73-77, 2010

    一般社団法人 日本内科学会

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