Subclinical Declines in the Verbal Fluency and Motor Regulation of Patients with AVIM (Asymptomatic Ventriculomegaly with Features of Idiopathic NPH on MRI): A Case-controlled Study

  • Iseki Chifumi
    Department of Neurology, Hematology, Metabolism, Endocrinology, and Diabetology, Faculty of Medicine, Yamagata University, Japan
  • Takahashi Yoshimi
    Department of Neurology, Hematology, Metabolism, Endocrinology, and Diabetology, Faculty of Medicine, Yamagata University, Japan
  • Wada Manabu
    Department of Neurology, Hematology, Metabolism, Endocrinology, and Diabetology, Faculty of Medicine, Yamagata University, Japan
  • Kawanami Toru
    Department of Neurology, Hematology, Metabolism, Endocrinology, and Diabetology, Faculty of Medicine, Yamagata University, Japan
  • Kato Takeo
    Department of Neurology, Hematology, Metabolism, Endocrinology, and Diabetology, Faculty of Medicine, Yamagata University, Japan

この論文をさがす

抄録

Objective We previously reported that, on brain MRI, iNPH features were observed in approximately 1% of asymptomatic elderly community dwellers. This phenomenon is designated asymptomatic ventriculomegaly with features of iNPH on MRI (AVIM). The aim of the present study was to clarify whether a subclinical decline in the neuropsychological function is present in patients with AVIM.<br> Methods We examined eight subjects with AVIM, six subjects with possible iNPH and 21 elderly controls. Neuropsychological tests were used, including the mini-mental state examination (MMSE), the Hasegawa dementia scale-revised (HDS-R), the frontal assessment battery (FAB), the trail making test A&B and semantic and letter verbal fluency tests.<br> Results When comparing the individuals with AVIM with the control subjects, significant differences were found in the scores achieved on the semantic verbal fluency tests and Luria's motor series (fist-edge-palm), a subtest of the FAB.<br> Conclusion The present study suggests that individuals with AVIM demonstrate a slight subclinical decline in the cognitive function and motor regulation, which may represent a prodromal stage of iNPH.<br>

収録刊行物

  • Internal Medicine

    Internal Medicine 52 (15), 1687-1690, 2013

    一般社団法人 日本内科学会

被引用文献 (1)*注記

もっと見る

参考文献 (7)*注記

もっと見る

詳細情報

問題の指摘

ページトップへ