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Genetic Study for Eating Disorders : From Candidate Gene Approaches to Genome Wide Associations Studies (GWAS)(Symposium/The Forefront of Eating Disorder Research)

  • Ando Tetsuya
    Department of Psychosomatic Research, National Institute of Mental Health, National Center of Neurology and Psychiatry

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Other Title
  • 摂食障害の遺伝子研究 : 候補遺伝子法から全ゲノム相関解析へ(シンポジウム:摂食障害研究の最前線,2008年,第49回日本心身医学会総会(札幌))
  • 摂食障害の遺伝子研究--候補遺伝子法から全ゲノム相関解析へ
  • セッショク ショウガイ ノ イデンシ ケンキュウ コウホ イデンシホウ カラ ゼン ゲノム ソウカン カイセキ エ

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Abstract

Genetic factors play a significant role in susceptibility to eating disorders such as anorexia nervosa (AN) and bulimia nervosa (BN). A sib-pair linkage study suggested a linkage region for restricting AN in chromosome 1, 2, 13 and that for BN in chromosome 10. Candidate-gene association studies indicated associations of SLC6A4, HTR2A and BDNF genes with AN in multiple studies. We found that ghrelin gene Leu72Met SNP, -3056T>C SNP, and their haplotype were associated with purging type BN. The same ghrelin gene SNPs were significantly associated with increased body mass index, fat mass, waist circumference, acylated ghrelin concentration and elevated scores in the Drive for Thinness-Body Dissatisfaction in non-clinical young female. In addition, the 3056T>C SNP of the ghrelin gene is related to the probability and rate of change from the restricting type AN to other phenotypes of eating disorders. Our genome-wide association analysis with microsatellite markers identified novel candidate loci for AN at 1q41 and 11q22 in Japanese. A genome-wide association study with SNP markers using recent microarray technique is a promising method in search for susceptibility genes of eating disorders.

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