1型糖尿病調査研究委員会報告―劇症1型糖尿病の新しい診断基準(2012)

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タイトル別名
  • Report of the Committee of the Japan Diabetes Society on the Research of Fulminant and Acute-onset Type 1 Diabetes Mellitus: New Diagnostic Criteria for Fulminant Type 1 Diabetes Mellitus (2012)
  • イインカイ ホウコク 1ガタ トウニョウビョウ チョウサ ケンキュウ イインカイ ホウコク : ゲキショウ 1ガタ トウニョウビョウ ノ アタラシイ シンダン キジュン(2012)

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We have revised a part of the diagnostic criteria for fulminant type 1 diabetes as "Criteria for definite diagnosis of fulminant type 1 diabetes mellitus (2012)". The new criteria were set both to express the essence of this disease associated with a rapid increase of the patients' blood glucose and to be highly sensitive to reduce the misdiagnosis. After analyzing the data of 382 patients with newly-diagnosed fulminant type 1 diabetes, we adopted a HbA1c level of 8.7 % (NGSP value) as the cut-off value. The new criterion had 100 % sensitivity and the best value by the ROC (receiver operation curve) analysis.<br> In addition, we added a comment that "This value (HbA1c <8.7 % in NGSP) is not applicable for patients with previously diagnosed glucose intolerance" to the new criteria, and also a comment that "An association with HLA DRB1*04: 05-DQB1*04: 01 has been reported" as a related finding.<br> We did not revise the screening criteria or the other parts of the diagnostic criteria, because they are still reliable.<br>

収録刊行物

  • 糖尿病

    糖尿病 55 (10), 815-820, 2012

    一般社団法人 日本糖尿病学会

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