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INTESTINAL FLORA OF INFANTS WITH COW MILK HYPERSENSITIVITY FED ON CASEIN-HYDROLYZED FORMULA SUPPLEMENTED RAFFINOSE

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  • 牛乳アレルギー児の腸内細菌叢とそれに及ぼすラフィノース添加カゼイン分解乳の影響

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Abstract

We studied the intestinal flora of infants with cow milk hypersensitivity fed on casein-hydrolyzed formula(MA-1)and the influence of that supplemented with Raffinose(MA-1[R]). Infants with cow milk hypersensitivity were fed with MA-1 for 2 weeks, after which the formula was changed to MA-1[R]. Fourteen subjects were enrolled in this study and divided into two groups ; three who fed with breast or conventional milk in addition to MA-1 or MA-1[R](BM group)and 11 mainly fed with MA-1 or MA-1[R](TF group). Intentinal flora was inventigated at two weeks after MA-1 feeding and at two weeks after MA-1[R]feeding, respectively. Bifidobacterium was detected as the most predominant bacteria in all examples in the BM group, and that count and the ratio in all becteria remained high even after changing MA-1 to MA-1[R]. On the other hand, bacteria count and ratios of Bifidobacterium in all bacteria were conspicuously low in the TF group as compared with the BM group. And with the change from MA-1 to MA-1[R]in the TF group, the bacterial number and the occupation ratio of Bifidobacterium were increased, and Enterobacteriaceae bacterial count and the occupation ratio were decreased. The change of the intensinal flora with MA-1[R]feeding was mainly caused by the breeding action of Raffinose on bifidobacteria. Further studies are needed from a viewpoint of clinical effectivesess about the influence of normalization of the intestinal flora for the treatment of food hypersensitivity.[

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