Epstein-Barr virus infection and related hematological diseases

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  • SAWADA Akihisa
    Hematology/Oncology, Osaka Medical Center and Research Institute for Maternal and Child Health

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  • EBウイルス感染と血液疾患
  • EB ウイルス カンセン ト ケツエキ シッカン

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Description

<p>Once the Epstein-Barr virus (EBV) has infected a person, it then latently infects B cells. This latent infection lasts a lifetime. However, EBV can infect T or NK cells (T/NK cells) in rare cases. Therefore, EBV causes various hematological diseases. Among these diseases, CAEBV is regarded as the most problematic because, although it is not particularly uncommon, the diagnostic tests for this disease are not covered by health insurance, a serious illness in the “non-active” periods is lacking, and the appropriate motivation for early initiation of treatment can easily be lost. However, the symptoms may suddenly change; and if the manifestations are resistant when such exacerbation occurs, CAEBC is potentially lethal. Allogeneic hematopoietic stem cell transplantation (HSCT) is the only cure. Once the diagnosis has been made, earlier treatment initiation, safer bridging to allogeneic HSCT with multi-drug chemotherapy, and then, planned HSCT can be completed more safely and thereby achieve a better outcome.</p>

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 57 (10), 2267-2274, 2016

    The Japanese Society of Hematology

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