{"@context":{"@vocab":"https://cir.nii.ac.jp/schema/1.0/","rdfs":"http://www.w3.org/2000/01/rdf-schema#","dc":"http://purl.org/dc/elements/1.1/","dcterms":"http://purl.org/dc/terms/","foaf":"http://xmlns.com/foaf/0.1/","prism":"http://prismstandard.org/namespaces/basic/2.0/","cinii":"http://ci.nii.ac.jp/ns/1.0/","datacite":"https://schema.datacite.org/meta/kernel-4/","ndl":"http://ndl.go.jp/dcndl/terms/","jpcoar":"https://github.com/JPCOAR/schema/blob/master/2.0/"},"@id":"https://cir.nii.ac.jp/crid/1390001205041065856.json","@type":"Article","productIdentifier":[{"identifier":{"@type":"DOI","@value":"10.2170/jjphysiol.53.377"}},{"identifier":{"@type":"COI","@value":"1:STN:280:DC%2BD2c%2Fos1Gkuw%3D%3D"}},{"identifier":{"@type":"PMID","@value":"14975184"}},{"identifier":{"@type":"NDL_BIB_ID","@value":"6832424"}},{"identifier":{"@type":"URI","@value":"http://id.ndl.go.jp/bib/6832424"}},{"identifier":{"@type":"URI","@value":"https://ndlsearch.ndl.go.jp/books/R000000004-I6832424"}},{"identifier":{"@type":"NAID","@value":"10011955403"}},{"identifier":{"@type":"URI","@value":"https://search.jamas.or.jp/link/ui/2004229936"}}],"resourceType":"学術雑誌論文(journal article)","dc:title":[{"@language":"en","@value":"Cardiopulmonary Hemodynamics of Blue-Sheep, Pseudois nayaur, as High-Altitude Adapted Mammals"}],"dc:language":"en","description":[{"type":"abstract","notation":[{"@language":"en","@value":"The blue-sheep, pika, and yak live in the Tibetan highlands at an altitude of 6,100 m and are typical mammals adapted to high-altitudes. These animals have a long history of habitation at high-altitudes and are considered to be \"animals completely adapted to high-altitudes\" because of their physiological and morphological traits that are well adapted to high-altitude environments. To evaluate the physiological characteristics of high-altitude adaptation in the blue-sheep, changes in the pulmonary hemodynamics during exposure to simulated-altitudes at 0, 2,300, and 4,500 m were examined by means of a climatic chamber in Qinghai Province, China (altitude 2,300 m). Seven blue-sheep inhabiting the mountains (3,000 m) of Qinghai Province, China, were compared with 5 pigs raised in the same area as controls. The primary items of measurement were the body weight (BW), systemic arterial pressure (Psa), pulmonary artery pressure (Ppa), hematocrit (Ht), left ventricular weight (LVW), right ventricular weight (RVW), and blood gas profile. The principal findings of this study are: (1) Ht, an index of right ventricular hypertrophy (RVW/LVW), and oxygen consumption (V˙O<sub>2</sub>) were significantly lower in the blue sheep compared with the pigs; (2) When the animals were exposed to simulated-altitudes at 0, 2,300, and 4,500 m, Ppa increased significantly in tandem with altitude elevation in both species, but the increases were significantly smaller in the blue-sheep; and (3) Ppa/Psa, an index of the right ventricular load, increased with the altitude in both species, but the increases were smaller in the blue sheep. From these observations, low Ht and RVW/LVW and significant attenuation of hypoxic pulmonary vasoconstriction (HPV) in the blue-sheep is considered to be characteristics of animals completely adapted to high-altitudes, such as the pika.<br>"}],"abstractLicenseFlag":"disallow"}],"creator":[{"@id":"https://cir.nii.ac.jp/crid/1030003658340450690","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"70020758"},{"@type":"NRID","@value":"1000070020758"},{"@type":"NRID","@value":"9000001003018"},{"@type":"NRID","@value":"9000350620054"},{"@type":"NRID","@value":"9000018324026"},{"@type":"NRID","@value":"9000364647805"},{"@type":"NRID","@value":"9000364639896"}],"foaf:name":[{"@language":"en","@value":"Sakai Akio"}],"jpcoar:affiliationName":[{"@language":"en","@value":"Department of Sports Medicine, Shinshu University School of Medicine"}]},{"@id":"https://cir.nii.ac.jp/crid/1420001326233507840","@type":"Researcher","personIdentifier":[{"@type":"KAKEN_RESEARCHERS","@value":"60199875"},{"@type":"NRID","@value":"1000060199875"},{"@type":"CINII_AUTHOR_ID","@value":"DA19578491"},{"@type":"URI","@value":"https://ci.nii.ac.jp/author/DA19578491#entity"},{"@type":"URI","@value":"https://viaf.org/viaf/NII%7CDA19578491"},{"@type":"NRID","@value":"9000002217124"},{"@type":"NRID","@value":"9000411591246"},{"@type":"NRID","@value":"9000242660173"},{"@type":"NRID","@value":"9000409861094"},{"@type":"NRID","@value":"9000002450385"},{"@type":"NRID","@value":"9000254358466"},{"@type":"NRID","@value":"9000409861081"},{"@type":"NRID","@value":"9000257762997"},{"@type":"NRID","@value":"9000401427306"},{"@type":"NRID","@value":"9000238237527"},{"@type":"NRID","@value":"9000254358732"},{"@type":"NRID","@value":"9000394465553"},{"@type":"NRID","@value":"9000293528076"},{"@type":"NRID","@value":"9000006377692"},{"@type":"NRID","@value":"9000020971814"},{"@type":"NRID","@value":"9000253499857"},{"@type":"NRID","@value":"9000399940721"},{"@type":"NRID","@value":"9000413896210"},{"@type":"NRID","@value":"9000254869336"},{"@type":"NRID","@value":"9000254358261"},{"@type":"NRID","@value":"9000006683580"},{"@type":"NRID","@value":"9000319550248"},{"@type":"NRID","@value":"9000257763043"},{"@type":"NRID","@value":"9000397973065"},{"@type":"NRID","@value":"9000253499775"},{"@type":"NRID","@value":"9000257762983"},{"@type":"NRID","@value":"9000318622114"},{"@type":"NRID","@value":"9000411591221"},{"@type":"NRID","@value":"9000254869935"},{"@type":"NRID","@value":"9000254869290"},{"@type":"NRID","@value":"9000413263313"},{"@type":"NRID","@value":"9000411590346"},{"@type":"NRID","@value":"9000411591276"},{"@type":"NRID","@value":"9000411600570"},{"@type":"NRID","@value":"9000411591203"},{"@type":"NRID","@value":"9000254358221"},{"@type":"NRID","@value":"9000254869469"},{"@type":"NRID","@value":"9000390903543"},{"@type":"NRID","@value":"9000317170922"},{"@type":"NRID","@value":"9000411591271"},{"@type":"NRID","@value":"9000254358963"},{"@type":"NRID","@value":"9000283506546"},{"@type":"NRID","@value":"9000363371390"},{"@type":"RESEARCHMAP","@value":"https://researchmap.jp/takaaki-matsumoto"}],"foaf:name":[{"@language":"en","@value":"Matsumoto Takaaki"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001205041065857","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Saitoh Muneo"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001205041065861","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Matsuzaki Tetsuya"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001205041065858","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000001118009"}],"foaf:name":[{"@language":"en","@value":"Koizumi Tomonobu"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001205041065859","@type":"Researcher","foaf:name":[{"@language":"en","@value":"Ishizaki Takeshi"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001205041065860","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000001118012"}],"foaf:name":[{"@language":"en","@value":"Ruan Zong Hai"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001205041065862","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000001118014"}],"foaf:name":[{"@language":"en","@value":"Wang Zhan Gang"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001205041065864","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000001118016"}],"foaf:name":[{"@language":"en","@value":"Chen Qiu Hong"}]},{"@id":"https://cir.nii.ac.jp/crid/1410001205041065856","@type":"Researcher","personIdentifier":[{"@type":"NRID","@value":"9000001118002"}],"foaf:name":[{"@language":"en","@value":"Wang Xiao Qin"}]}],"publication":{"publicationIdentifier":[{"@type":"PISSN","@value":"0021521X"},{"@type":"EISSN","@value":"18811396"},{"@type":"CODEN","@value":"JJPHAM"},{"@type":"NDL_BIB_ID","@value":"000000120340"},{"@type":"ISSN","@value":"0021521X"},{"@type":"LISSN","@value":"0021521X"},{"@type":"NCID","@value":"AA00691224"}],"prism:publicationName":[{"@language":"en","@value":"The Japanese Journal of Physiology"},{"@language":"en","@value":"JJP"},{"@language":"en","@value":"Jpn.J.Physiol"}],"dc:publisher":[{"@language":"en","@value":"THE PHYSIOLOGICAL SOCIETY OF JAPAN"},{"@language":"ja","@value":"一般社団法人　日本生理学会"}],"prism:publicationDate":"2003","prism:volume":"53","prism:number":"5","prism:startingPage":"377","prism:endingPage":"384"},"reviewed":"false","dcterms:accessRights":"http://purl.org/coar/access_right/c_abf2","url":[{"@id":"http://id.ndl.go.jp/bib/6832424"},{"@id":"https://ndlsearch.ndl.go.jp/books/R000000004-I6832424"},{"@id":"https://search.jamas.or.jp/link/ui/2004229936"}],"availableAt":"2003","foaf:topic":[{"@id":"https://cir.nii.ac.jp/all?q=blue-sheep","dc:title":"blue-sheep"},{"@id":"https://cir.nii.ac.jp/all?q=high-altitude","dc:title":"high-altitude"},{"@id":"https://cir.nii.ac.jp/all?q=pulmonary%20hypertension","dc:title":"pulmonary hypertension"},{"@id":"https://cir.nii.ac.jp/all?q=right%20ventricular%20hypertrophy","dc:title":"right ventricular 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Seasonal and latitudinal changes in hematocrit and right ventricular weights of wood mice, Apodemus argenteusu"}]},{"@id":"https://cir.nii.ac.jp/crid/1572824499811907456","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Blunted hypoxic pulmonary vasoconstrictive response in the rodent Ochotona cuzoniae (pika) at high altitude"}]},{"@id":"https://cir.nii.ac.jp/crid/1572824499811911680","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Exaggerated pulmonacrotaline in rats susceptible to chronic mountain sickness"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105974788620928","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Physiological effects of high altitude on the pulmonary circulation"}]},{"@id":"https://cir.nii.ac.jp/crid/1573105974788621952","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Polycythemia and right ventricular hypertrophy"}]},{"@id":"https://cir.nii.ac.jp/crid/1573387449765332992","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Comparison of muscular pulmonary arteries in low and high altitude hamsters and rats"}]},{"@id":"https://cir.nii.ac.jp/crid/1573668924742039296","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Hemodynamic responses to acute hypoxia, hypobaria, and exercise in subjects susceptible to high-altitude pulmonary edema"}]},{"@id":"https://cir.nii.ac.jp/crid/1573668924742041472","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Lung vascular smooth muscle as a determinant of pulmonary hypertension at high altitude"}]},{"@id":"https://cir.nii.ac.jp/crid/1573950399718751232","@type":"Article","relationType":["cites"],"jpcoar:relatedTitle":[{"@language":"en","@value":"Differences in acute hypoxic pulmonary vasoresponsiveness between rat strains : role of endothelium"}]}],"dataSourceIdentifier":[{"@type":"JALC","@value":"oai:japanlinkcenter.org:0023609961"},{"@type":"NDL_SEARCH","@value":"oai:ndlsearch.ndl.go.jp:R000000004-I6832424"},{"@type":"CROSSREF","@value":"10.2170/jjphysiol.53.377"},{"@type":"PUBMED","@value":"14975184"},{"@type":"CIA","@value":"10011955403"},{"@type":"OPENAIRE","@value":"doi_dedup___::e891099804f57fc1eecda81f5aa9da8c"}]}