Ground-based assessment of JAXA mouse habitat cage unit by mouse phenotypic studies
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- Shimbo Miki
- Mouse Epigenetics Project, ISS/Kibo experiment, JAXA, Japan Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Japan Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan
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- Kudo Takashi
- Mouse Epigenetics Project, ISS/Kibo experiment, JAXA, Japan Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Japan Laboratory Animal Resource Center, University of Tsukuba, Japan
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- Hamada Michito
- Mouse Epigenetics Project, ISS/Kibo experiment, JAXA, Japan Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Japan Laboratory Animal Resource Center, University of Tsukuba, Japan
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- Jeon Hyojung
- Mouse Epigenetics Project, ISS/Kibo experiment, JAXA, Japan Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Japan Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan
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- Imamura Yuki
- Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Japan Master’s Program in Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan
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- Asano Keigo
- Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Japan Master’s Program in Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan
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- Okada Risa
- Mouse Epigenetics Project, ISS/Kibo experiment, JAXA, Japan Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Japan
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- Tsunakawa Yuki
- Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Japan Ph.D. Program in Human Biology, School of Integrative and Global Majors, University of Tsukuba, Japan
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- Mizuno Seiya
- Laboratory Animal Resource Center, University of Tsukuba, Japan Department of Laboratory Animal Science, Faculty of Medicine, University of Tsukuba, Japan
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- Yagami Ken-ichi
- Mouse Epigenetics Project, ISS/Kibo experiment, JAXA, Japan Laboratory Animal Resource Center, University of Tsukuba, Japan Department of Laboratory Animal Science, Faculty of Medicine, University of Tsukuba, Japan
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- Ishikawa Chihiro
- Department of Neurobiology, Faculty of Medicine, University of Tsukuba, Japan Doctoral Program in Kansei, Behavioral and Brain Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan
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- Li Haiyan
- Department of Neurobiology, Faculty of Medicine, University of Tsukuba, Japan Doctoral Program in Kansei, Behavioral and Brain Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Japan
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- Shiga Takashi
- Mouse Epigenetics Project, ISS/Kibo experiment, JAXA, Japan Department of Neurobiology, Faculty of Medicine, University of Tsukuba, Japan
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- Ishida Junji
- Mouse Epigenetics Project, ISS/Kibo experiment, JAXA, Japan Graduate School of Life and Environmental Sciences, University of Tsukuba, Japan Life Science Center, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan
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- Hamada Juri
- Graduate School of Life and Environmental Sciences, University of Tsukuba, Japan Life Science Center, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan
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- Murata Kazuya
- Life Science Center, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan
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- Ishimaru Tomohiro
- Graduate School of Life and Environmental Sciences, University of Tsukuba, Japan
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- Hashimoto Misuzu
- Ph.D. Program in Human Biology, School of Integrative and Global Majors, University of Tsukuba, Japan
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- Fukamizu Akiyoshi
- Mouse Epigenetics Project, ISS/Kibo experiment, JAXA, Japan Graduate School of Life and Environmental Sciences, University of Tsukuba, Japan Life Science Center, Tsukuba Advanced Research Alliance (TARA), University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan
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- Yamane Mutsumi
- Mouse Epigenetics Project, ISS/Kibo experiment, JAXA, Japan Research Institute for Microbial Diseases, Osaka University, Suita, Japan
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- Ikawa Masahito
- Mouse Epigenetics Project, ISS/Kibo experiment, JAXA, Japan Research Institute for Microbial Diseases, Osaka University, Suita, Japan
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- Morita Hironobu
- Mouse Epigenetics Project, ISS/Kibo experiment, JAXA, Japan Department of Physiology, Gifu University Graduate School of Medicine, Yanagido, Gifu 501-1194, Japan
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- Shinohara Masahiro
- Mouse Epigenetics Project, ISS/Kibo experiment, JAXA, Japan Department of Systems BioMedicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, 113-8510, Japan
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- Asahara Hiroshi
- Mouse Epigenetics Project, ISS/Kibo experiment, JAXA, Japan Department of Systems BioMedicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, 113-8510, Japan
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- Akiyama Taishin
- Mouse Epigenetics Project, ISS/Kibo experiment, JAXA, Japan Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan
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- Akiyama Nobuko
- Division of Cellular and Molecular Biology, The Institute of Medical Science, The University of Tokyo, Tokyo 108-8639, Japan
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- Sasanuma Hiroki
- Laboratory of Developmental Genetics, Center for Experimental Medicine and Systems Biology, The Institute of Medical Sciences, The University of Tokyo, Minato-Ku, Tokyo 108-8639, Japan
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- Yoshida Nobuaki
- Mouse Epigenetics Project, ISS/Kibo experiment, JAXA, Japan Laboratory of Developmental Genetics, Center for Experimental Medicine and Systems Biology, The Institute of Medical Sciences, The University of Tokyo, Minato-Ku, Tokyo 108-8639, Japan
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- Zhou Rui
- Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 4-1-3106, Tsukuba, Ibaraki 305-8562, Japan Key Laboratory of Medical Electrophysiology, Ministry of Education, Collaborative Innovation Center for Prevention and Treatment of Cardiovascular Disease/Institute of Cardiovascular Research, Sichuan Medical University, Luzhou, Sichuan, P.R. China
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- Wang Ying-Ying
- Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 4-1-3106, Tsukuba, Ibaraki 305-8562, Japan
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- Ito Taito
- Graduate School of Life and Environmental Sciences, University of Tsukuba, Japan Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 4-1-3106, Tsukuba, Ibaraki 305-8562, Japan
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- Kokubu Yuko
- Graduate School of Life and Environmental Sciences, University of Tsukuba, Japan Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 4-1-3106, Tsukuba, Ibaraki 305-8562, Japan
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- Noguchi Taka-aki K.
- Graduate School of Life and Environmental Sciences, University of Tsukuba, Japan Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 4-1-3106, Tsukuba, Ibaraki 305-8562, Japan
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- Ishimine Hisako
- Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 4-1-3106, Tsukuba, Ibaraki 305-8562, Japan
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- Kurisaki Akira
- Mouse Epigenetics Project, ISS/Kibo experiment, JAXA, Japan Graduate School of Life and Environmental Sciences, University of Tsukuba, Japan Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 4-1-3106, Tsukuba, Ibaraki 305-8562, Japan
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- Shiba Dai
- Mouse Epigenetics Project, ISS/Kibo experiment, JAXA, Japan JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Ibaraki 305-8505, Japan
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- Mizuno Hiroyasu
- Mouse Epigenetics Project, ISS/Kibo experiment, JAXA, Japan JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Ibaraki 305-8505, Japan
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- Shirakawa Masaki
- Mouse Epigenetics Project, ISS/Kibo experiment, JAXA, Japan JEM Utilization Center, Human Spaceflight Technology Directorate, JAXA, Tsukuba, Ibaraki 305-8505, Japan
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- Ito Naoki
- Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, 187-8502, Japan
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- Takeda Shin
- Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, 187-8502, Japan
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- Takahashi Satoru
- Mouse Epigenetics Project, ISS/Kibo experiment, JAXA, Japan Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba, Japan Laboratory Animal Resource Center, University of Tsukuba, Japan
この論文をさがす
抄録
The Japan Aerospace Exploration Agency developed the mouse Habitat Cage Unit (HCU) for installation in the Cell Biology Experiment Facility (CBEF) onboard the Japanese Experimental Module (“Kibo”) on the International Space Station. The CBEF provides “space-based controls” by generating artificial gravity in the HCU through a centrifuge, enabling a comparison of the biological consequences of microgravity and artificial gravity of 1 g on mice housed in space. Therefore, prior to the space experiment, a ground-based study to validate the habitability of the HCU is necessary to conduct space experiments using the HCU in the CBEF. Here, we investigated the ground-based effect of a 32-day housing period in the HCU breadboard model on male mice in comparison with the control cage mice. Morphology of skeletal muscle, the thymus, heart, and kidney, and the sperm function showed no critical abnormalities between the control mice and HCU mice. Slight but significant changes caused by the HCU itself were observed, including decreased body weight, increased weights of the thymus and gastrocnemius, reduced thickness of cortical bone of the femur, and several gene expressions from 11 tissues. Results suggest that the HCU provides acceptable conditions for mouse phenotypic analysis using CBEF in space, as long as its characteristic features are considered. Thus, the HCU is a feasible device for future space experiments.
収録刊行物
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- Experimental Animals
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Experimental Animals 65 (2), 175-187, 2016
公益社団法人 日本実験動物学会
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詳細情報 詳細情報について
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- CRID
- 1390001205044904960
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- NII論文ID
- 130005152402
- 40020802785
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- NII書誌ID
- AA11032321
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- ISSN
- 18817122
- 00075124
- 13411357
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- NDL書誌ID
- 027252324
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- PubMed
- 26822934
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可