メフエナム酸の解熱効果に関する検討

DOI Web Site PubMed

書誌事項

タイトル別名
  • Clinical Study on Antipyretic Effect of Mefenamic Acid
  • メフェナム酸の解熱効果に関する検討 二重盲検試験
  • メフェナムサン ノ ゲネツ コウカ ニ カンスル ケントウ ニジュウ モウケンシケン
  • 二重盲検試験

この論文をさがす

説明

Antipyretic effect of mefenamic acid (Pontal) now widely used as sedative was evaluated in patients with fever by double blind method. Aspirin was used as the control drug.<BR>Patients with fever of 37.5°C or more before treatment were included in this study. Origin of fever was various but in about 80% of the cases fever was caused by acute upper respiratory infections. Each patient was given 500mg (for adults) or 375mg (for children) of either mefenamic acid or aspirin 3 times for 24 hours. Fever was measured within 30 minutes before and 2, 4, 6 and 8 hours after treatment.<BR>Total of 287 cases including 35 drop out cases were collected. Finally, antipyretic effect in 124 cases of mefenamic acid and 128 of aspirin was evaluated clinically and compared statistically. For statistical analysis, time (hours) and doses of drugs required for getting afebrile, degrees of antipyretic effect at 2, 4, 6 and 8 hours after treatment and “fever area” on the chart were used as the parameters for comparison of two groups.<BR>Both, mefenamic acid and aspirin showed marked antipyretic effect and there appeared to be no significant differences in two groups, though in judgement by degree of the effect by hour and “fever area” mefenamic acid was considered to be a little more effective than aspirin.<BR>No severe side effects were observed in both groups throughout the study.<BR>Thus, the results obtained suggest that mefenamic acid has antipyretic effect not at all inferior to aspirin and may be useful in practice as antipyretic drug as well as sedative.

収録刊行物

  • 感染症学雑誌

    感染症学雑誌 48 (1), 24-32, 1974

    一般社団法人 日本感染症学会

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ